N-[芴甲氧羰基]-O-甲基-D-丝氨酸 | 1279032-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: N-[芴甲氧羰基]-O-甲基-D-丝氨酸
• 中文别名: 芴甲氧羰基-O-甲基-D-丝氨酸
• 英文名称: Fmoc-D-Ser(Me)-OH
• 英文别名: Fmoc-O-methyl-D-Ser；(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxypropanoic acid
• CAS: 1279032-69-7
• 化学式: C₁₉H₁₉NO₅
• 分子量: 341.364
• InChiKey: YFWAFELGMGZCHL-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Fmoc-DiMeGln 、 2-chlorotrityl chloride polystyrene resin 、 Fmoc-甘氨酸 、 N-[芴甲氧羰基]-O-甲基-D-丝氨酸 、 芴甲氧羰基-L-苏氨酸 、 (2S,3S)-Fmoc-Thr(NHBoc)-OH 生成
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Compounds for enzyme inhibition
  申请人：Zhou Han-Jie

  公开号：US20070105786A1

  公开（公告）日：2007-05-10

  Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. Oral administration of these peptide-based proteasome inhibitors is possible due to their bioavailability profiles

  基于肽的化合物，包括含杂原子的三元环，能够高效且选择性地抑制与蛋白酶体相关的N-末端亲核（Ntn）水解酶的特定活性。这些基于肽的化合物包括环氧化物或氮杂环丙烷，并在N-末端进行官能化。除了其他治疗用途外，预计这些基于肽的化合物将显示抗炎性能和抑制细胞增殖。由于它们的生物利用度特性，这些基于肽的蛋白酶体抑制剂可以通过口服给药进行。
• Compounds for Enzyme Inhibition
  申请人：Zhou Han-Jie

  公开号：US20090203698A1

  公开（公告）日：2009-08-13

  Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. Oral administration of these peptide-based proteasome inhibitors is possible due to their bioavailability profiles.
• APPLICATION OF BIOFILM FORMATION INHIBITING COMPOUNDS ENHANCES CONTROL OF CITRUS CANKER
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US20160021882A1

  公开（公告）日：2016-01-28

  Citrus canker caused by the bacterium Xanthomonas citri subsp. citri (Xac) is an economically important disease of citrus worldwide. Biofilm formation plays an important role in early infection of Xac on host leaves. In this study, we assessed the hypothesis that small molecules able to inhibit biofilm formation reduce Xac infection and enhance the control of citrus canker disease. D-leucine and 3-indolylacetonitrile (IAN) were found to prevent biofilm formation by Xac on different abiotic surfaces and host leaves at a concentration lower than the minimum inhibitory concentration (MIC). Quantitative real time reverse transcription polymerase chain reaction (qRT-PCR) analysis indicated that IAN repressed expression of chemotaxis/motility-related genes in Xac. In laboratory experiments, planktonic and biofilm cells of Xac treated with D-leucine and IAN, either alone or in combination, were more susceptible to copper (CuSO4) than those untreated. In greenhouse assays, D-leucine and IAN applied alone, or combined with copper reduced both the number of canker lesions and bacterial populations of Xac on citrus host leaves. This study provides the basis for the use of foliar-applied biofilm inhibitors for the control of citrus canker alone or combined with copper-based bactericides.
• US7687456B2
  申请人：——

  公开号：US7687456B2

  公开（公告）日：2010-03-30
• US8716322B2
  申请人：——

  公开号：US8716322B2

  公开（公告）日：2014-05-06