1-[4-(4-Ethylphenyl)sulfonyl-1,4-diazepan-1-yl]ethanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-(4-Ethylphenyl)sulfonyl-1,4-diazepan-1-yl]ethanone
• 化学式: C₁₅H₂₂N₂O₃S
• 分子量: 310.4
• InChiKey: ODSWDFSFDCLMTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  66.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1
  申请人：Schering Corporation

  公开号：EP2190820A2

  公开（公告）日：2010-06-02
• [EN] SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1<br/>[FR] SULFONAMIDES À SUBSTITUTION AZÉPINE ET DIAZÉPINE UTILISÉS POUR INHIBER LA 11-BÊTA-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE-1
  申请人：SCHERING CORP

  公开号：WO2009023664A2

  公开（公告）日：2009-02-19

  In its many embodiments, the present invention relates to a novel class of substituted azepine- and diazepine-sulfonamide compounds useful to inhibit 11BETA-hydroxysteroid dehydrogenase type-1, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the expression of 11BETA-hydroxysteroid dehydrogenase type-1 using such compounds or pharmaceutical compositions.