α-benzoylaminomethyl-acetoacetic acid ethyl ester | 182248-07-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-benzoylaminomethyl-acetoacetic acid ethyl ester
• 英文别名: ethyl 5-benzoylamino-3-oxopentanoate；Ethyl 5-benzamido-3-oxopentanoate
• CAS: 182248-07-3
• 化学式: C₁₄H₁₇NO₄
• 分子量: 263.293
• InChiKey: AUEGELUUAICFHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD FOR PRODUCING OPTICALLY ACTIVE 2-(N-SUBSTITUTED AMINOMETHYL)-3-HYDROXYBUTYRIC ACID ESTER
  申请人：Yasohara Yoshihiko

  公开号：US20090104671A1

  公开（公告）日：2009-04-23

  The present invention relates to a method for producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters wherein a 2-(N-substituted aminomethyl)-3-oxobutyric acid ester is treated with an enzyme source capable of stereoselectively reducing said ester to the corresponding optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid ester having the (2S,3R) configuration. The present invention provides an efficient method for industrially producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters, in particular such compounds having the (2S,3R) configuration, which are useful as intermediates for the production of medicinal compounds, among others.

  本发明涉及一种制备光学活性的2-(N-取代氨甲基)-3-羟基丁酸酯的方法，其中将2-(N-取代氨甲基)-3-氧代丁酸酯与能够立体选择性还原所述酯的酶源处理，以得到相应的具有(2S,3R)构型的光学活性的2-(N-取代氨甲基)-3-羟基丁酸酯。本发明提供了一种高效的工业制备光学活性的2-(N-取代氨甲基)-3-羟基丁酸酯的方法，特别是具有(2S,3R)构型的化合物，这些化合物可用作药物化合物的中间体等。
• 3-[4-HETEROCYCLYL -1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：EP1887003A1

  公开（公告）日：2008-02-13

  Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

  公开的式(I)化合物 可抑制参与炎症过程的细胞因子的产生，因此可用于治疗涉及炎症的疾病和病理状况，如慢性炎症性疾病。还公开了制备这些化合物的工艺和包含这些化合物的药物组合物。
• Method for producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid ester
  申请人：KANEKA CORPORATION

  公开号：EP2357248A1

  公开（公告）日：2011-08-17

  The present invention relates to a method for producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters wherein a 2-(N-substituted aminomethyl)-3-oxobutyric acid ester is treated with an enzyme source capable of stereoselectively reducing said ester to the corresponding optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid ester having the (2S,3R) configuration. The present invention provides an efficient method for industrially producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters, in particular such compounds having the (2S,3R) configuration, which are useful as intermediates for the production of medicinal compounds, among others.

  本发明涉及一种生产光学活性 2-(N-取代氨甲基)-3-羟基丁酸酯的方法。 本发明涉及一种生产光学活性 2-(N-取代氨基甲基)-3-羟基丁酸酯的方法，其中 2-(N-取代氨基甲基)-3-氧代丁酸酯用一种酶源处理，该酶源能够立体选择性地将所述酯还原为具有 (2S,3R) 构型的相应光学活性 2-(N-取代氨基甲基)-3-羟基丁酸酯。本发明提供了一种工业化生产光学活性 2-(N-取代氨甲基)-3-羟基丁酸酯的有效方法。 氨基甲基）-3-羟基丁酸酯，特别是具有 (2S,3R) 构型的此类化合物的有效方法，这些化合物可用作生产药用化合物等的中间体。
• US5599954A
  申请人：——

  公开号：US5599954A

  公开（公告）日：1997-02-04