4-Chloro-N-(2-{2-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}-2-oxoethyl)-N-methylbenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Chloro-N-(2-{2-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}-2-oxoethyl)-N-methylbenzamide
• 英文别名: 4-chloro-N-[2-[2-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-oxoethyl]-N-methylbenzamide
• 化学式: C₂₃H₂₂Cl₂N₄O₃
• 分子量: 473.3
• InChiKey: IGSGLLWINDOSIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  79.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• VITAMIN D PROMOTING SUNSCREEN
  申请人：Armstrong, Ernest T.

  公开号：EP2384193A2

  公开（公告）日：2011-11-09
• VITAMIN D FORMING SUNSCREEN
  申请人：Armstrong Ernest T.

  公开号：US20110268678A1

  公开（公告）日：2011-11-03

  A composition suitable for providing protection against ultraviolet radiation containing one or more active ultraviolet radiation absorber through which ultraviolet radiation in approximately the 295 to 315 nanometer range is permitted to enter the skin in an amount sufficient for the body to produce a healthful and disease-opposing quantity of vitamin D 3 and chemical precursors thereof. The composition is particularly used in sunscreens promoting on the one hand vitamin D 3 production, on the other hand protecting the skin against harmful ultraviolet radiation.
• US9724544B2
  申请人：——

  公开号：US9724544B2

  公开（公告）日：2017-08-08
• [EN] VITAMIN D PROMOTING SUNSCREEN<br/>[FR] ECRAN SOLAIRE FAVORISANT LA VITAMINE D
  申请人：ARMSTRONG ERNEST T

  公开号：WO2010076731A2

  公开（公告）日：2010-07-08

  A composition suitable for providing protection against ultraviolet radiation containing one or more active ultraviolet radiation absorber through which ultraviolet B radiation is permitted to enter the skin in an amount sufficient for the body to produce a healthful and disease-opposing quantity of vitamin D3 and chemical precursors thereof. The composition is particularly used in sunscreens promoting on the one hand vitamin D3 production, on the other hand protecting the skin against harmful ultraviolet radiation.
• [EN] SUNSCREEN COMPOSITION WITH ENHANCED PHOTOPROTECTION<br/>[FR] COMPOSITION D'ÉCRAN SOLAIRE À PHOTOPROTECTION AMÉLIORÉE
  申请人：[en]EDGEWELL PERSONAL CARE BRANDS, LLC

  公开号：WO2022260691A1

  公开（公告）日：2022-12-15

  A sunscreen composition includes a sunscreen active, a carrier, and a film former polymer. The sunscreen active may be selected from organic sunscreen actives. The carrier may include an amphiphile monolayer to encapsulate a least a portion of the total amount of the sunscreen active. The film former polymer may include an acrylic film former polymer selected from C1-C30alkyl (meth)acrylates copolymer. Notably, the sunscreen active may provide enhanced photoprotection at relatively low concentration levels when present with the carrier, including the amphiphile monolayer, and the acrylic film former polymer.