o-Trifluormethylphthalsaeure | 24913-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-Trifluormethylphthalsaeure
• 英文别名: 3-Trifluormethyl-phthalsaeure；trifluoromethylphthalic acid；3-trifluoromethylphthalic acid；3-(trifluoromethyl)phthalic Acid
• CAS: 24913-62-0
• 化学式: C₉H₅F₃O₄
• 分子量: 234.132
• InChiKey: VZPPTOVECQZCTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-三氟甲基萘 在 吡啶 、 potassium permanganate 作用下， 生成 o-Trifluormethylphthalsaeure
  参考文献：
  名称：

  Kunshenko,B.V. et al., Journal of Organic Chemistry USSR (English Translation), 1974, vol. 10, p. 1715 - 1720

  摘要：

  DOI：

文献信息

• New phenylalanine derivatives
  申请人：AJINOMOTO CO. INC

  公开号：US20030220318A1

  公开（公告）日：2003-11-27

  Specific phenylalanine derivatives or pharmaceutically acceptable. salts thereof have an antagonistic effect on the &agr;4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which &agr;4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

  特定的苯丙氨酸衍生物或其药用可接受的盐对α4整合素具有拮抗作用，因此，它们可用作治疗剂或预防剂，用于α4整合素依赖性粘附过程参与病理的疾病，如炎症性疾病、类风湿性关节炎、炎症性肠病、系统性红斑狼疮、多发性硬化症、舍格伦综合症、哮喘、银屑病、过敏、糖尿病、心血管疾病、动脉硬化、再狭窄、肿瘤增殖、肿瘤转移和移植排斥。
• NEW PHENYLALANINE DERIVATIVES
  申请人：SUZUKI Nobuyasu

  公开号：US20090048236A1

  公开（公告）日：2009-02-19

  Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which α4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

  特定的苯丙氨酸衍生物或其药学上可接受的盐具有对α4整合素的拮抗作用，因此可用作治疗剂或预防剂，用于α4整合素依赖性黏附过程参与病理的疾病，如炎症性疾病、类风湿性关节炎、炎症性肠病、系统性红斑狼疮、多发性硬化症、干燥综合症、哮喘、银屑病、过敏、糖尿病、心血管疾病、动脉硬化、再狭窄、肿瘤增殖、肿瘤转移和移植排斥。
• Positively-chargeable charge control agent and toner for developing electrostatic images
  申请人：ORIENT CHEMICAL INDUSTRIES, LTD.

  公开号：EP0881545A1

  公开（公告）日：1998-12-02

  Positively-chargeable charge control agent and toner for developing electrostatic images that comprises a coloring agent, a resin for toners, and said positively-chargeable charge control agent. The positively-chargeable charge control agent comprises a metal complex salt or metal complex of an aromatic dicarboxylic acid having at least 1 perfluoroalkyl group, wherein the central atom of the metal complex salt or metal complex is a trivalent metal.

  用于显影静电图像的正电荷控制剂和墨粉，包括着色剂、墨粉用树脂和所述正电荷控制剂。正电荷控制剂包括金属络合盐或至少有一个全氟烷基的芳香族二羧酸的金属络合物，其中金属络合盐或金属络合物的中心原子为三价金属。
• NOVEL PHENYLALANINE DERIVATIVES
  申请人：Ajinomoto Co., Inc.

  公开号：EP1323711A1

  公开（公告）日：2003-07-02

  Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which α4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

  特定的苯丙氨酸衍生物或其药学上可接受的盐类对 α4 整合素具有拮抗作用，因此可作为治疗剂或预防剂用于治疗 α4 整合素依赖性粘附过程参与病理的疾病、如炎症性疾病、类风湿性关节炎、炎症性肠病、系统性红斑狼疮、多发性硬化症、Sjögren's 综合征、哮喘、牛皮癣、过敏、糖尿病、心血管疾病、动脉硬化、再狭窄、肿瘤增殖、肿瘤转移和移植排斥反应。
• MEHJKOSI GIDZYUTSU NYUSU, 1979, HO 332,
  作者：

  DOI：——

  日期：——