N-isopropyl-N-(4-hydroxyphenyl)-acetamide | 91457-26-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-isopropyl-N-(4-hydroxyphenyl)-acetamide
• 英文别名: acetic acid-(4-hydroxy-N-isopropyl-anilide)；Essigsaeure-(4-hydroxy-N-isopropyl-anilid)；N-isopropyl-4'-hydroxyacetanilide；N-isopropyl-4'-hydroxy-acetanilide；N-(4-hydroxyphenyl)-N-propan-2-ylacetamide
• CAS: 91457-26-0
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: VJWKAKGJVGNGLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(isopropylamino)phenol 在 sodium hydroxide 作用下， 生成 N-isopropyl-N-(4-hydroxyphenyl)-acetamide
  参考文献：
  名称：

  Ashley et al., Journal of the Chemical Society, 1958, p. 3298,3308

  摘要：

  DOI：

文献信息

• N-alkyl-4'-hydroxyacetanilides, pharmaceutical compositions comprising
  申请人：——

  公开号：US04520134A1

  公开（公告）日：1985-05-28

  N-alkyl-4'-hydroxyacetanilides wherein alkyl is of up to 8 carbon atoms, preferably ethyl or isopropyl, have analgesic, antipyretic, anti-inflammatory and sedative activity. Those of at least two carbon atoms lack the hepatotoxicity of acetaminophen and the N-methyl compound also has substantially less hepatotoxicity than acetaminophen. Pharmaceutical compositions comprising them are employed to ameliorate pain, reduce fever, reduce the symptoms of systemic inflammatory conditions and sedate.

  N-烷基-4'-羟基乙酰苯胺，其中烷基含有不超过8个碳原子，优选乙基或异丙基，具有镇痛、退热、抗炎和镇静活性。至少含有两个碳原子的化合物不具有对乙酰氨基酚的肝毒性，而N-甲基化合物的肝毒性也显著低于乙酰氨基酚。包含它们的制药组合物用于缓解疼痛、降低发热、减轻全身炎症症状并镇静。
• ROSEN, G. M.
  作者：ROSEN, G. M.

  DOI：——

  日期：——
• N-ALKYL-4'-HYDROXYACETANILIDES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE
  申请人：ROSEN, Gerald M.

  公开号：EP0116637A1

  公开（公告）日：1984-08-29
• EP0116637A4
  申请人：——

  公开号：EP0116637A4

  公开（公告）日：1985-02-18
• Multi-API Loading Prodrugs
  申请人：Zeidan Tarek A.

  公开号：US20120202823A1

  公开（公告）日：2012-08-09

  The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.