Benzyl-p-phthalimidophenylether | 20012-62-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: Benzyl-p-phthalimidophenylether
• 英文别名: N-(4-benzyloxy-phenyl)-phthalimide；2-(4-Benzyloxy-phenyl)-isoindole-1,3-dione；2-(4-phenylmethoxyphenyl)isoindole-1,3-dione
• CAS: 20012-62-8
• 化学式: C₂₁H₁₅NO₃
• mdl: MFCD00187340
• 分子量: 329.355
• InChiKey: JUOUMGCILMRHIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Benzyl-p-phthalimidophenylether 在 palladium on activated charcoal 氢气 作用下， 以95%的产率得到N-(4-羟苯基)邻苯二甲酰亚胺
  参考文献：
  名称：

  New selective O-debenzylation of phenol with Mg/MeOH

  摘要：

  Carboxylate-benzyl and nitro-benzyl groups used in phenols protection were selectively debenzylated with 3-25 equiv of Mg in methanol at room temperature. Good yields of the desired phenols were obtained within 3-10 h from a wide variety of O-(carboxylate-benzyl)- or O-(nitro-benzyl)-phenols. Selective O-debenzylation was possible in the presence of O-(carboxylate-benzyl)- or O-(nitro-benzyl)-phenols with Mg/MeOH. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2005.06.046

文献信息

• New selective O-debenzylation of phenol with Mg/MeOH
  作者：Wei Huang、Xu Zhang、Hong Liu、Jianhua Shen、Hualiang Jiang

  DOI：10.1016/j.tetlet.2005.06.046

  日期：2005.8

  Carboxylate-benzyl and nitro-benzyl groups used in phenols protection were selectively debenzylated with 3-25 equiv of Mg in methanol at room temperature. Good yields of the desired phenols were obtained within 3-10 h from a wide variety of O-(carboxylate-benzyl)- or O-(nitro-benzyl)-phenols. Selective O-debenzylation was possible in the presence of O-(carboxylate-benzyl)- or O-(nitro-benzyl)-phenols with Mg/MeOH. (c) 2005 Published by Elsevier Ltd.