1-<1-(2-Naphthyl)cyclohexyl>piperidine | 81490-58-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-<1-(2-Naphthyl)cyclohexyl>piperidine
• 英文别名: Piperidine, 1-[1-(2-naphthalenyl)cyclohexyl]-；1-(1-naphthalen-2-ylcyclohexyl)piperidine
• CAS: 81490-58-6
• 化学式: C₂₁H₂₇N
• 分子量: 293.452
• InChiKey: PGMJLKNHMKMIJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-哌啶-1-基环己烷甲腈 、 2-naphthalenylmagnesium bromide 以 四氢呋喃 为溶剂， 反应 6.0h， 以65%的产率得到1-<1-(2-Naphthyl)cyclohexyl>piperidine
  参考文献：
  名称：

  Fotadar, Upinder, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 11, p. 1006 - 1007

  摘要：

  DOI：

文献信息

• Arylcyclohexylamines derived from BTCP are potent indirect catecholamine agonists
  作者：AT Ilagouma、T Maurice、D Duterte-Boucher、E Coderc、J Vignon、J Costentin、JM Kamenka

  DOI：10.1016/0223-5234(93)90124-w

  日期：1993.1

  N-[1-(2-Benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP)-related molecules were prepared by means of chemical modulation of the 3 rings which constitute this dopamine (DA) and norepinephrine (NE) uptake inhibitor. Tested in vitro (binding to the DA uptake complex and to the PCP receptor sites, inhibition of the synaptosomal uptake of DA and NE) and in vivo (locomotor activity in mice) these molecules showed good homogeneity of action. The newly prepared structures, although formally related to the phencyclidine (PCP) structural model, no longer display significant affinity for the PCP receptor. These compounds behave like a new series of indirect potent stimulants of the dopaminergic and noradrenergic systems leading to potential antidepressive compounds.
• FOTADAR, UPINDER, INDIAN J. CHEM., 1981, 20, N 11, 1006-1007
  作者：FOTADAR, UPINDER

  DOI：——

  日期：——
• US5248686A
  申请人：——

  公开号：US5248686A

  公开（公告）日：1993-09-28
• Fotadar, Upinder, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 11, p. 1006 - 1007
  作者：Fotadar, Upinder

  DOI：——

  日期：——