申请人:Delamarre Soazig Claude Marie
公开号:US20120282299A1
公开(公告)日:2012-11-08
The present invention relates to a coating comprising at least one biodegradable polymer, wherein the polymer comprises at least one or a blend of a poly (ester amide) (PEA) having a chemical formula described by structural formula (II), wherein; R
1
is independently selected from the group consisting of (C
2
-C
20
)alkylene, (C
2
-C
20
)alkenylene, —(R
9
—CO—O—R
10
—O—CO—R
9
)—, CHR
11
—O—CO—R
12
—COOCR
11
— and combinations thereof; R
3
and R
4
in a single co-monomer m or p, respectively, are independently selected from the group consisting of hydrogen, (C
1
-C
6
)alkyl, (C
2
-C
6
)alkenyl, (C
2
-C
6
)alkynyl, (C
6
-C
10
)aryl, (C
1
C
6
)alkyl, —(CH
2
)SH, —(CH
2
)
2
S(CH
3
), CH
2
OH, —CH(OH)CH
3
, —(CH
2
)
4
NH
3
+, ˜(CH
2
)
3
NHC(═NH
2
+)NH
2
, —CH
2
COOH, (CH
2
)COOH, —CH
2
—CO—NH
2
—CH
2
CH
2
—CO—NH
2
, —CH
2
CH
2
COOH, CH
3
—CH
2
—CH(CH
3
)—, formula (a), HO—
P
-Ph-CH
2
—, (CH
3
)
2
—CH—, Ph-NH—, NH—(CH
2
)
3
—C—, NH—CH═N—CH═C—CH
2
—. R
5
or R
6
are independently selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols or from the group consisting of (C
2
-C
20
)alkylene, (C
2
-C
20
)alkenylene, alkyloxy, oligoethyleneglycol with a Mw ranging from 44 Da up to 700 Da, —CH
2
—CH—(CH
2
OH)
2
, CH
2
CH(OH)CH
2
whereby R
5
and R
6
are non identical. R
7
is hydrogen, (C
6
-C
10
) aryl, (C
1
C
6
) alkyl or a protecting group such as benzyl- or a bioactive agent; R
8
is independently (C
1
-C
20
) alkyl or (C
2
-C
20
)alkenyl; R
9
or R
10
are independently selected from C
2
-C
12
alkylene or C
2
-C
12
alkenylene and R
11
or R
12
are independently selected from H, methyl, C
2
-C
12
alkylene or C
2
-C
12
alkenylene.