5-Ethyl-2-phenoxyphenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Ethyl-2-phenoxyphenol
• 化学式: C₁₄H₁₄O₂
• 分子量: 214.26
• InChiKey: XZOPHRPAUNJURP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Diphenyl ether antimicrobial compounds
  申请人：Tonge J. Peter

  公开号：US20060041025A1

  公开（公告）日：2006-02-23

  The present invention is directed to compounds having the formula: wherein A 1 , A 3 , A 6 , and A 8 independently represent CH or N; A 2 represents N or C—X 1 a —R 1 ; A 4 represents N or C—X 2 b —R 2 ; R 1 and R 2 independently represent H, or a hydrocarbon containing a minimum of one carbon atom and a maximum of twenty six carbon atoms, wherein the hydrocarbon is unsubstituted, or is substituted with one or more of —OH, —NH 2 , —SH, halo, or —COOH; X 1 and X 2 independently represent —O—, —S—, —NH—, —C(O)O—, —C(O)—, —C(O)NH—, or —SO 2 NH—; a and b independently represent 0 or 1, provided that when a and b are both 0, then R 1 and R 2 are not both H; when a is 1, then R 1 is not H; and when b is 1, then R 2 is not H; A 5 and A 9 independently represent CR 3 or N; R 3 represents H, methyl, ethyl, or halo; A 7 represents CR 4 or N; R 4 represents H, methyl, ethyl, halo, nitro, hydroxy, amino, amido, or a methyl or ethyl group substituted with halo, nitro, hydroxy, amino, or amido; provided that A 2 and A 4 are not both N; and not more than three of A 5 , A 6 , A 7 , A 8 , and A 9 are N. The invention is also directed to pharmaceutical compositions comprising a compound according to (1) and a pharmaceutically acceptable carrier. The invention is also directed to methods of inhibiting the growth of a bacterium containing an enoyl reductase enzyme encoded by a fabI gene, a fabK gene, a fabL gene, or a combination thereof, in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a compound according to formula (1).

  本发明涉及具有以下式的化合物：其中A1、A3、A6和A8独立地表示CH或N；A2表示N或C-X1a-R1；A4表示N或C-X2b-R2；R1和R2独立地表示H，或含有至少一个碳原子和最多二十六个碳原子的碳氢化合物，其中该碳氢化合物未经取代或用一种或多种-OH、NH2、SH、卤素或-COOH取代；X1和X2独立地表示-O-、-S-、-NH-、-C（O）O-、-C（O）-、-C（O）NH-或-SO2NH-；a和b独立地表示0或1，但当a和b都为0时，R1和R2不同时为H；当a为1时，R1不为H；当b为1时，R2不为H；A5和A9独立地表示CR3或N；R3表示H、甲基、乙基或卤素；A7表示CR4或N；R4表示H、甲基、乙基、卤素、硝基、羟基、氨基、酰胺基或用卤素、硝基、羟基、氨基或酰胺基取代的甲基或乙基基团；其中A2和A4不同时为N；且A5、A6、A7、A8和A9中不超过三个为N。本发明还涉及包含式（1）的化合物和药学上可接受的载体的制药组合物。本发明还涉及一种抑制哺乳动物中编码fabI基因、fabK基因、fabL基因或其组合的烯醇还原酶酶的细菌的生长的方法，该方法包括向哺乳动物中施加有效量的符合式（1）的化合物。
• Pyridone FabI inhibitors and uses thereof
  申请人：The Research Foundation for The State University of New York

  公开号：US10071965B2

  公开（公告）日：2018-09-11

  The present invention provides novel 2-pyridone compounds and 4-pyridone compounds and methods of treating a subject infected with a pathogen of Staphylococcus aureus, Mycobacterium tuberculosis, Francisella tularensis, Burkholderia pseudomallei, Yersinia pestis, Escherichia coli and Proteus mirabilisone.

  本发明提供了新型 2-吡啶酮化合物和 4-吡啶酮化合物，以及治疗感染了金黄色葡萄球菌、结核分枝杆菌、土拉弗氏菌、假马来伯克霍尔德氏菌、鼠疫耶尔森氏菌、大肠埃希菌和奇异变形杆菌病原体的受试者的方法。
• METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC TO TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND
  申请人：Ronnett, Gabrielle

  公开号：EP2655706A2

  公开（公告）日：2013-10-30
• Fungicide N-Cyclopropyl-Sulfonylamide Derivatives
  申请人：Schwarz Hans-Georg

  公开号：US20090137611A1

  公开（公告）日：2009-05-28

  The present invention relates to N-cyclopropyl-sulfonylamide derivatives of formula (I) wherein the substituents are cyclic groups, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions: (I)
• Pyridone FabI Inhibitors and Uses Thereof
  申请人：The Research Foundation for the State University of New York

  公开号：US20160376235A1

  公开（公告）日：2016-12-29

  The present invention provides novel 2-pyridone compounds and 4-pyridone compounds and methods of treating a subject infected with a pathogen of Staphylococcus aureus, Mycobacterium tuberculosis, Francisella tularensis, Burkholderia pseudomallei, Yersinia pestis, Escherichia coli and Proteus mirabilisone.