茚-1,2,3-三酮,水合物 | 2462-59-1

• 分子结构分类: 有机化合物 - 苯类化合物
• 中文名称: 茚-1,2,3-三酮,水合物
• 英文名称: ninhydrin
• 英文别名: 1H-Indene-1,2,3-trione hydrate；indene-1,2,3-trione;hydrate
• CAS: 2462-59-1
• 化学式: C₉H₄O₃*H₂O
• 分子量: 178.144
• InChiKey: MFLQZSRHKVDEOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.03
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  茚-1,2,3-三酮,水合物 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以80%的产率得到ninhydrinoxime
  参考文献：
  名称：

  Paria; Thokdar; Majumdar, Journal of the Indian Chemical Society, 1990, vol. 67, # 6, p. 532 - 532

  摘要：

  DOI：

文献信息

• Side-bonded ketone complexes of platinum(<scp>0</scp>). Indan-1,2,3-trione complexes; molecular and crystal structure of [2,2′,-bis(indan-1,2,3-trionato)(2–)-O²O^2′]bis(triphenylphosphine)platinum
  作者：Martin M. Hunt、Raymond D. W. Kemmitt、David R. Russell、Paul A. Tucker

  DOI：10.1039/dt9790000287

  日期：——

  five-membered 1,3-dioxa-2-platinolan ring. Ring-expansion reactions of [Pt(int)L2] and ring-substitution reactions of [Pt(int)2}L2], with hexafluoropropan-2-one and hexafluorobut-2-yne are also described. Reactions with hexafluoropropan-2-one give both five- and seven-membered ring systems. The side-bonded complexes [Pt(int)L2] react with dioxygen to give cyclic dicarboxylato-complexes.

  等摩尔量的[PtL 4 ]（L = PPh 3或AsPh 3）与indan -1,2,3-trione（int）或2,2-di-hydroxyindan-1,3-dione的反应产生-结合的酮配合物[Pt（int）L 2 ]与int进行扩环反应，得到[Pt （int）2 } L 2 ]。加合物[Pt （int）2 }（PPh 3）2 ]的晶体是单斜晶，空间群Cc的a = 22.08，b = 14.47，c = 30.72Å，β= 95.1°，Z = 8。结构参数的平方细化降低了R到0.078进行了2382次反射。该加合物具有两个通过中心羰基的碳原子连接并通过这些基团上的氧原子与铂键合的茚满-1,2,3-三酮部分，从而得到五元的1,3-二氧杂-2 -platinolan戒指。还描述了[Pt（int）L 2 ]的扩环反应和[Pt （int）2 } L 2 ]与六氟丙烷-2-酮和六氟丁-2
• Carbomolybdate clusters formed by carbonyl insertion into molybdenum-oxygen bonds. Structural investigation of the [RMo4O15X]3− core (R  C9H4O, X  OCH3; R  C14H10, X  C7H5O2; R  C14H8, X  OH)
  作者：Chen Qin、Liu Shuncheng、Zhu Huizhe、Zubieta Jon

  DOI：10.1016/s0277-5387(00)86291-9

  日期：1989.1

  in this position, while II possesses a benzoate ligand with an unusual μ 3 -O,O′coordination mode. Complex III presents a hydroxy-group unsymmetrically bonded to three of the molybdenum centres. The stereochemical consequences of the various coordination modes are discussed. Crystal data: Compound I , monoclinic space group Pc , a = 24.888(2), b = 12.897(3), c = 24.900(3) A, β = 101.94(2)°, D calc =

  摘要[C 4 H 9）4 N] 2 [Mo 2 O 7]与多种包含α-二酮基团的有机物种反应，得到一般组成为[RMo 4 O 15 X] 3-的四核配合物。配合物[（C 4 H 9）4 N] 3 [（C 9 H 4 O）Mo 4 O 15（OCH 3）]（I），[（C 4 H 9）4 N] 3 [（C 14 H合成了10）Mo 4 O 15（C 6 H 5 CO 2）]（11）和[（C 4 H 9）4 N] 3 [（C 14 H 8）Mo 4 O 15（OH）]（III）二钼酸与茚三酮，苯甲酰和菲醌的反应。配合物II也可以由二钼酸盐和安息香在乙腈-甲醇溶液中制备，并与双核物质[（C 4 H 9）4 N] 2 [Mo 2 O 5（C 6 H 5 C（O ）C（O）C 6 H 5）2]·CH 3 CN·CH 3 OH（IV）。配合物I–III具有四核核心，先前对α-乙二醛衍生物[（C 4 H 9）4
• SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS
  申请人：Hemmerling Hans-Jorg

  公开号：US20100056599A1

  公开（公告）日：2010-03-04

  Synthesis of novel substituted indeno[1,2-b]indole derivatives of the type of 5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-diones and 5H-indeno[1,2-b]indole-6,9,10-triones, which show pronounced inhibition of the human protein kinase CK2, and the use thereof as active ingredients in medicaments and/or drug products in particular for the treatment of neoplastic diseases.

  合成新型取代的indeno[1,2-b]indole衍生物，包括5,6,7,8-四氢indeno[1,2-b]indole-9,10-二酮和5H-indeno[1,2-b]indole-6,9,10-三酮，这些衍生物表现出明显的人类蛋白激酶CK2的抑制作用，并将其用作药物的活性成分，尤其用于治疗肿瘤疾病。
• Substituted indeno [1,2-b]indole derivatives as novel inhibitors of protein kinase CK2 and their use as tumor therapeutic agents, cytostatics and diagnostic aids
  申请人：Heinrich-Heine Universitat Dusseldof

  公开号：US08133913B2

  公开（公告）日：2012-03-13

  Synthesis of novel substituted indeno[1,2-b]indole derivatives of the type of 5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-diones and 5H-indeno[1,2-b]indole-6,9,10-triones, which show pronounced inhibition of the human protein kinase CK2, and the use thereof as active ingredients in medicaments and/or drug products in particular for the treatment of neoplastic diseases.

  合成新型取代的吲哚并[1,2-b]吲哚衍生物，包括5,6,7,8-四氢吲哚并[1,2-b]吲哚-9,10-二酮和5H-吲哚并[1,2-b]吲哚-6,9,10-三酮，这些衍生物表现出对人类蛋白激酶CK2的显著抑制作用，并将其用作药物的活性成分，特别是用于治疗肿瘤性疾病。
• Quantitative analysis apparatus and method
  申请人：BIO-METRICS SYSTEMS, INC.

  公开号：EP0088636A2

  公开（公告）日：1983-09-14

  A method and apparatus for the quantitative determination of an analyte in a liquid employs a liquid-permeable solid medium defining a liquid flow path. The medium includes a number of reactant-containing reaction zones spaced apart along the flow path and in which reaction occurs with the analyte or an analyte derivative (e.g., a labelled analyte) to result in the formation of a predetermined product. Detector means are employed to detect analyte, analyte derivative, reactant or predetermined product in the reaction zones, the number of such zones in which such detection occurs indicating the amount of analyte in the liquid.

  一种定量测定液体中分析物的方法和装置采用了一种限定液体流动路径的液体渗透性固体介质。介质包括若干沿流动路径间隔开的含反应物的反应区，在这些反应区中与被分析物或被分析物衍生物（如标记的被分析物）发生反应，形成预定产物。检测器用于检测反应区中的被分析物、被分析物衍生物、反应物或预定产物，发生这种检测的反应区的数量表示液体中被分析物的数量。