1-[4-(1-phenyl-1-(3-hydroxymethylphenyl)-methylene)-piperidin-1-yl]-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-6-azaindol-3-yl]-ethane-1,2-dione | 676490-22-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-(1-phenyl-1-(3-hydroxymethylphenyl)-methylene)-piperidin-1-yl]-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-6-azaindol-3-yl]-ethane-1,2-dione
• 英文别名: 1-[4-[[3-(hydroxymethyl)phenyl]-phenyl-methylene]-1-piperidyl]-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione；1-[4-[[3-(hydroxymethyl)phenyl]-phenylmethylidene]piperidin-1-yl]-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione
• CAS: 676490-22-5
• 化学式: C₃₂H₃₀N₆O₄
• 分子量: 562.628
• InChiKey: RQEILVZSTMHSQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  42
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
  申请人：——

  公开号：US20040063744A1

  公开（公告）日：2004-04-01

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: 1 wherein: Z is 2 Q is selected from the group consisting of: 3 —W— is 4

  这项发明提供了具有药物和生物影响性能的化合物，它们的药物组合物和使用方法。具体而言，该发明涉及具有独特抗病毒活性的新哌啶4-烯基衍生物。更具体地说，本发明涉及用于治疗艾滋病毒和艾滋病的化合物。本发明的化合物为一般式I的化合物： 1 其中： Z是 2 Q是从以下组中选择的： 3 —W—是 4
• INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC 4-ALKENYL PIPERIDINE AMIDES
  申请人：Wang Tao

  公开号：US20080188481A1

  公开（公告）日：2008-08-07

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is

  本发明提供了具有药物和生物影响性质的化合物，它们的制药组合物和使用方法。具体而言，本发明涉及具有独特的抗病毒活性的新的哌啶4-烯基衍生物。更具体地，本发明涉及用于治疗HIV和艾滋病的化合物。本发明的化合物一般公式为I：其中：Z是Q是从以下组中选择的：-W-是
• US7348337B2
  申请人：——

  公开号：US7348337B2

  公开（公告）日：2008-03-25
• US7915283B2
  申请人：——

  公开号：US7915283B2

  公开（公告）日：2011-03-29
• [EN] INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC 4-ALKENYL PIPERIDINE AMIDES<br/>[FR] INDOLE, AZAINDOLE ET AMIDES HETEROCYCLIQUES DE 4-ALCENYL-PIPERIDINE APPARENTES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004043337A2

  公开（公告）日：2004-05-27

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: (I) wherein: Z is ; Q is selected from the group consisting of: ; -W-is .