3-phenyl-2-penten-1-amine | 94521-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenyl-2-penten-1-amine
• 英文别名: 3-Aethyl-cinnamylamin；3-Phenylpent-2-en-1-amine；3-phenylpent-2-en-1-amine
• CAS: 94521-87-6
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: DARPFFGVRDNUCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-phenyl-2-pentenenitrile 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 3-phenyl-2-penten-1-amine
  参考文献：
  名称：

  Testa,E. et al., Justus Liebigs Annalen der Chemie, 1964, vol. 676, p. 160 - 167

  摘要：

  DOI：

文献信息

• Testa,E. et al., Justus Liebigs Annalen der Chemie, 1964, vol. 676, p. 160 - 167
  作者：Testa,E. et al.

  DOI：——

  日期：——
• Synthesis and histamine H2 agonistic activity of arpromidine analogues: replacement of the pheniramine-like moiety by non-heterocyclic groups
  作者：A Buschauer、A Friese-Kimmel、G Baumann、W Schunack

  DOI：10.1016/0223-5234(92)90145-q

  日期：1992.6

  Analogues of the potent histamine H-2 agonist arpromidine, characterized by non-heterocyclic groups (phenyl, cyclo-hexyl, alkyl) instead of the pheniramine-like portion, were prepared and tested for their H-2 agonistic and H-1 antagonistic activity in the isolated guinea pig right atrium and ileum, respectively. In the diphenylpropylguanidine series an increase in H-2 agonistic potency resulted from mono- or difluorination at one or both phenyl rings in the meta and/or para position (pD2 less-than-or-equal-to 7.75 vs pD2 = 7.15 for the unsubstituted parent compound). Compounds chlorinated at both phenyl rings were considerably less potent. Highest combined H-2 agonistic/H-1 antagonistic potency was found in the 4-fluorophenyl series. The arpromidine analogue with cyclohexyl and methyl group instead of phenyl and pyridine ring proved to be 30 times more potent than histamine in the atrium. The H-1 antagonistic potency in cyclohexyl compounds was lower than in the diaryl series. Thus, aromatic rings appear not to be required for high H-2 agonistic potency but are useful for combined H-2 agonistic/H-1 antagonistic activity.