[Hydroxy(phenyl)methyl] formate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Hydroxy(phenyl)methyl] formate
• 化学式: C₈H₈O₃
• 分子量: 152.15
• InChiKey: AEFFLWXRUFFURA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE
  申请人：Signal Pharmaceuticals, LLC

  公开号：US20150210650A1

  公开（公告）日：2015-07-30

  Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

  本文提供了与2-(叔丁基氨基)-4-((1R,3R,4R)-3-羟基-4-甲基环己基氨基)-嘧啶-5-羧酰胺相关的配方、工艺、固体形式和使用方法。
• COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION
  申请人：Boy Kenneth M.

  公开号：US20120028994A1

  公开（公告）日：2012-02-02

  The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.

  本公开提供一系列公式(I)的化合物，可调节β-淀粉样肽（β-AP）的产生，并在治疗阿尔茨海默病和其他受β-淀粉样肽（β-AP）产生影响的疾病中有用。
• Antibody-active agent conjugates and methods of use
  申请人：LegoChem Biosciences, Inc.

  公开号：US10583197B2

  公开（公告）日：2020-03-10

  The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).

  本发明提供了具有可被异戊烯基转移酶识别的氨基酸基团的蛋白质-活性剂共轭物。本发明还提供了含有该共轭物的组合物。本发明进一步提供了使用共轭物将活性剂递送至靶细胞的方法，以及使用共轭物治疗有需要的受试者（如需要活性剂的受试者）的方法。
• PROTEIN-ACTIVE AGENT CONJUGATES AND METHOD FOR PREPARING THE SAME
  申请人：LegoChem Biosciences, Inc.

  公开号：EP2707031B1

  公开（公告）日：2019-06-26
• ANTIBODY-ACTIVE AGENT CONJUGATES AND METHODS OF USE
  申请人：LegoChem Biosciences, Inc.

  公开号：US20140161829A1

  公开（公告）日：2014-06-12

  The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).