2-amino-1-methylpyridinium p-toluenesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-1-methylpyridinium p-toluenesulfonate
• 英文别名: 4-Methylbenzenesulfonate;1-methylpyridin-1-ium-2-amine
• 化学式: C₆H₉N₂*C₇H₇O₃S
• 分子量: 280.348
• InChiKey: GAZDPFZZKIQQOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.99
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-ethyl-5-(1-methyl-1H-quinolin-2-ylidene)-2-methylsulfanyl-4-oxo-4,5-dihydro-3-thiazolium p-toluenesulfonate 、 2-amino-1-methylpyridinium p-toluenesulfonate 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Synthesis and Antimalarial Efficacy of Aza-Fused Rhodacyanines in Vitro and in the P. berghei Mouse Model

  摘要：

  Several aza-fused rhodacyanines were synthesized and assessed for their in vitro and in vivo antimalarial activities against Plasmodium falciparum K1 and P. berghei. All synthetic compounds showed strong selective antimalarial in vitro activity. Class II azarhodacyanines, 3, consisting of four heterocyclic units, were found to display good parasitemia suppression and low acute toxicity in vivo. Among them, 3c appeared to be the most effective at a dose of 20-25 mg kg-1 day-1 (ip).

  DOI：

  10.1021/jm0606241

文献信息

• PHARMACEUTICAL COMPOSITION COMPRISING AZARHODACYANINE COMPOUND AS ACTIVE INGREDIENT
  申请人：Japan Science and Technology Agency

  公开号：EP1894920A1

  公开（公告）日：2008-03-05

  The object of the invention is to provide pharmaceutical composition that can be used as a therapeutic and/or prophylactic agent. Particularly, the pharmaceutical composition of the invention has significant therapeutic effect and survival benefit for the disease caused by parasitic protozoa, and selective toxicity against the causative protozoa. The pharmaceutical composition comprises a compound represented by general formula (1). Particularly, the invention relates to a composition that is an effective therapeutic/prophylactic agent for malaria, leishmania, African sleeping sickness, Chagas disease, toxoplasmosis lymphatic filariasis, babesiosis, and coccidiosis, and a novel compound contained therein.

  本发明的目的是提供可用作治疗和/或预防剂的药物组合物。特别是，本发明的药物组合物对寄生原虫引起的疾病有显著的治疗效果和生存益处，并对致病原虫有选择性毒性。该药物组合物包含通式（1）所代表的化合物。特别是，本发明涉及一种对疟疾、利什曼病、非洲昏睡病、南美锥虫病、弓形虫病淋巴丝虫病、巴贝丝虫病和球虫病具有有效治疗/预防作用的组合物，以及其中所含的一种新型化合物。
• WO2006/137258
  申请人：——

  公开号：——

  公开（公告）日：——