methyl (3S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (3S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
• 化学式: C₁₇H₂₁NO₄
• 分子量: 303.35
• InChiKey: ZPUCINDJVBIVPJ-YFXXHVASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] COCAINE ANALOGS AND METHODS OF PREPARATION AND USES THEREOF<br/>[FR] ANALOGUES DE COCAÏNE ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：UNIV TEMPLE

  公开号：WO2012009263A1

  公开（公告）日：2012-01-19

  The invention provides novel cocaine analogs. The invention also provides a method of preparing cocaine analogs with control over the substituents installed at the C-1, C-2, C-3, C-4 and N-8 positions of the tropane bicyclic scaffold. The invention further provides a method of providing anesthesia to a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a compound of the invention. The invention also provides a method of blocking reuptake of a monoamine neurotransmitter in a subject in need thereof, to a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a compound of the invention.

  该发明提供了新型可卡因类似物。该发明还提供了一种制备可卡因类似物的方法，该方法可以控制在Tropane双环支架的C-1、C-2、C-3、C-4和N-8位置安装的取代基。该发明还提供了一种给需要麻醉的受试者提供麻醉的方法，包括向受试者注射包含该发明化合物的药物组合物。该发明还提供了一种阻止需要单胺神经递质再摄取的受试者的方法，包括向受试者注射包含该发明化合物的药物组合物。
• Immunogenic Conjugates for Producing Immune Responses to Drugs of Abuse and Methods of Use
  申请人：Mizel Steven B.

  公开号：US20120171239A1

  公开（公告）日：2012-07-05

  The present invention is based, in part, on flagellin adjuvants that enhance immune responses directed against drugs of abuse. Provided are conjugates comprising a flagellin adjuvant covalently linked to a drug of abuse or an immunologically similar derivative thereof. Also provided are methods of making the conjugates of the invention and use thereof for administration to a subject, e.g., to produce an immune response in the subject against the drug of abuse, to prevent addiction to the drug of abuse in the subject, to reduce the effect of the drug of abuse in the subject, to reduce the level of the drug of abuse in the brain of the subject, and/or to reduce the addiction in the subject to the drug of abuse.

  本发明部分基于增强针对药物滥用的免疫反应的鞭毛蛋白佐剂。提供的是包括鞭毛蛋白佐剂的共轭物，其与药物滥用或其免疫学上类似的衍生物共价连接。同时提供了制备该发明中的共轭物的方法，并用于向受试者施用，例如，在受试者中产生针对药物滥用的免疫反应，预防受试者对药物滥用的成瘾，减轻受试者对药物滥用的影响，降低受试者大脑中药物滥用的水平，以及/或减轻受试者对药物滥用的成瘾。
• Method of treating disease
  申请人：Crews Thomas M

  公开号：US11123284B2

  公开（公告）日：2021-09-21

  The present disclosure relates to methods for treating a variety of diseases and/or ameliorating pain by administering to the ear canal of a subject a composition.

  本公开涉及通过向受试者的耳道施用组合物来治疗各种疾病和/或改善疼痛的方法。
• Delivery of Serotonin Receptor Antagonists By Microinjection Systems
  申请人：Deasey Anthony P.

  公开号：US20120143119A1

  公开（公告）日：2012-06-07

  In an aspect of the invention, serotonin receptor antagonist formulations are provided for subcutaneous, transdermal or intradermal delivery to a subject. In an embodiment, serotonin receptor antagonist formulations include ondansetron or ondansetron-containing formulations. In another embodiment, serotonin receptor antagonist formulations include palonosetron or palonosetron-containing formulations. In another aspect of the invention, microinjection devices are provided for delivering a serotonin receptor antagonist formulation to a subject.
• Cocaine Analogs and Methods of Preparation and Uses Thereof
  申请人：Davis Franklin A.

  公开号：US20120329828A1

  公开（公告）日：2012-12-27

  The invention provides novel cocaine analogs. The invention also provides a method of preparing cocaine analogs with control over the substituents installed at the C-1, C-2, C-3, C-4 and N-8 positions of the tropane bicyclic scaffold. The invention further provides methods of providing anesthesia, blocking reuptake of a monoamine neurotransmitter, and treating depression, by administering to a subject in need of such treatment a pharmaceutical composition comprising a compound of the invention.

表征谱图