Isosalvianolic acid B

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: Isosalvianolic acid B
• 英文别名: 2-[(E)-3-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoic acid
• 化学式: C₃₆H₃₀O₁₆
• 分子量: 718.6
• InChiKey: SNKFFCBZYFGCQN-BJMVGYQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  52
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  278
• 氢给体数：
  9
• 氢受体数：
  16

文献信息

• PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP4023227A1

  公开（公告）日：2022-07-06

  Provided is a pharmaceutical composition and application thereof, specifically, said pharmaceutical composition comprises: salvianolic acid B as a first active ingredient; and ginsenoside Rg1 as a second active ingredient, and the weight ratio of the first active ingredient to the second active ingredient being 5: (1-4.5). The pharmaceutical composition has a better active-ingredient proportion than the prior art, has a better therapeutic efficacy in preventing and/or treating ischemic diseases, and ischemia-reperfusion tissue or organ damage, and can be used for treating ischemia and/or ischemia-reperfusion damage of different tissues and organs.

  本发明提供了一种药物组合物及其应用，具体而言，所述药物组合物包括：作为第一活性成分的丹参酚酸B；作为第二活性成分的人参皂苷Rg1，第一活性成分与第二活性成分的重量比为5：（1-4.5）。与现有技术相比，该药物组合物的活性成分配比更合理，在预防和/或治疗缺血性疾病、缺血再灌注组织或器官损伤方面具有更好的疗效，可用于治疗不同组织器官的缺血和/或缺血再灌注损伤。
• Topical formulation and uses thereof
  申请人：McKay Larry

  公开号：US10322155B2

  公开（公告）日：2019-06-18

  The present invention provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analog or derivative thereof and (ii) a penetration enhancer, and optionally including tannic acid, or an analog or derivative thereof. The present invention also provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analog or derivative thereof, and (ii) tannic acid, or an analog or derivative thereof, optionally including a penetration enhancer. Also provided are kits and methods of prophylactic or therapeutic treatment of inflammatory and/or degenerative conditions using the combination of active ingredients as herein described.

  本发明提供了一种局部制剂，包括(i)紫草或紫草衍生化合物，或其类似物或衍生物，和(ii)渗透增强剂，并可选择包括单宁酸，或其类似物或衍生物。本发明还提供了一种局部制剂，包括（i）紫草或紫草衍生化合物，或其类似物或衍生物，以及（ii）单宁酸，或其类似物或衍生物，可选择包括渗透促进剂。此外，还提供了使用本文所述活性成分组合预防或治疗炎症和/或退行性病症的试剂盒和方法。
• Type of aryl benzofuran amidated derivative and medical use thereof
  申请人：CHINA PHARMACEUTICAL UNIVERSITY

  公开号：US11021454B2

  公开（公告）日：2021-06-01

  The present invention relates to a type of aryl benzofuran amidated derivatives, the medical use thereof, and the preparation method; said derivatives have antioxidation activity, and xanthine oxidase inhibitory activity, and can be used for antioxidation and for preparing compositions, drugs and health products and treating gout and hyperuricemia.

  本发明涉及一种芳基苯并呋喃酰胺化衍生物及其医疗用途和制备方法；所述衍生物具有抗氧化活性和黄嘌呤氧化酶抑制活性，可用于抗氧化，制备组合物、药物和保健品，治疗痛风和高尿酸血症。
• Antiviral compositions and methods of use
  申请人：Johns Hopkins University

  公开号：US20020151584A1

  公开（公告）日：2002-10-17

  Purified antiviral compounds, pharmaceutical formulations containing the compounds, and methods of use of the compounds are provided. The compositions of the invention are isolated antiviral components from plant extracts derived from, for example, Salvia miltiorrhiza , that find use in the treatment of viral infections, such as by inhibiting the activity of viral integrase. Methods for isolation and purification of the antiviral compounds are additionally provided.

  本发明提供了纯化的抗病毒化合物、含有该化合物的药物制剂以及该化合物的使用方法。本发明的组合物是从例如以下植物提取物中分离出的抗病毒成分、 丹参 ，可用于治疗病毒感染，例如通过抑制病毒整合酶的活性。此外，还提供了抗病毒化合物的分离和纯化方法。
• [EN] AMIDATED ARYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL USE THEREOF<br/>[FR] DÉRIVÉS D'ARYLBENZOFURANE AMIDÉ ET LEUR UTILISATION PHARMACEUTIQUE<br/>[ZH] 一种芳基苯并呋喃类酰胺化衍生物及医药用途
  申请人：UNIV CHINA PHARMA

  公开号：WO2017133464A1

  公开（公告）日：2017-08-10

  本发明公开了一种芳基苯并呋喃类酰胺化衍生物及医药用途、制备方法，该衍生物具备抗氧化的活性，具备黄嘌呤氧化酶抑制活性，能用于制备抗氧化、治疗痛风及高尿酸血症的组合物、药物、保健品。