N-(2-Hydroxy-ethyl)-tetraiod-phthalimid | 90947-81-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(2-Hydroxy-ethyl)-tetraiod-phthalimid
• 英文别名: 2-(2-hydroxyethyl)-4,5,6,7-tetraiodo-1H-isoindole-1,3(2H)-dione；2-(2-hydroxyethyl)-4,5,6,7-tetraiodoisoindole-1,3-dione
• CAS: 90947-81-2
• 化学式: C₁₀H₅I₄NO₃
• 分子量: 694.773
• InChiKey: UAIXXDYNQPBCRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四碘邻苯二甲酸酐 、 C.I.酸性橙108 在 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 19.0h， 以33%的产率得到N-(2-Hydroxy-ethyl)-tetraiod-phthalimid
  参考文献：
  名称：

  Iodine-containing radial-shaped macromolecular compounds, preparation method thereof and contrast media compositions for CT comprising the same

  摘要：

  本文披露了一种含碘的径向形状大分子，适用于计算机断层扫描（CT）造影剂的活性成分，以及一种制备该大分子的方法和包括该大分子的造影剂组合物。就本发明的含碘径向形状大分子而言，与当前含碘小分子造影剂化合物相比，对比增强的持续时间显著提高。

  公开号：

  US09387267B2

文献信息

• IODINE-CONTAINING RADIAL-SHAPED MACROMOLECULAR COMPOUNDS, PREPARATION METHOD THEREOF AND CONTRAST MEDIA COMPOSITIONS FOR CT COMPRISING THE SOME
  申请人：Kim Yoonkyung

  公开号：US20130150529A1

  公开（公告）日：2013-06-13

  Disclosed herein is an iodine-containing radial-shaped macromolecule suitable for an active ingredient of the computed tomography (CT) contrast medium, a method to prepare the same, and a contrast medium composition including the same. With respect to the iodine-containing radial-shaped macromolecule according to the present invention, the duration of contrast enhancement has been significantly improved in comparison to that of the current small molecular contrast media compounds containing iodine.

  本文揭示了一种含碘的径向形状的大分子，适用于计算机断层扫描（CT）造影剂的活性成分，以及制备该大分子的方法，以及包括该大分子的造影剂组合物。就本发明的含碘径向形状的大分子而言，与当前含碘的小分子造影剂相比，对比增强的持续时间显著提高。
• RADIAL SHAPE OF POLYMER COMPOUND CONTAINING IODINE, PREPARATION METHOD THEREOF, AND CT CONTRAST MEDIUM COMPOSITION CONTAINING SAME
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：EP2604289A2

  公开（公告）日：2013-06-19

  Disclosed herein is an iodine-containing radial-shaped macromolecule suitable for an active ingredient of the computed tomography (CT) contrast medium, a method to prepare the same, and a contrast medium composition including the same. With respect to the iodine-containing radial-shaped macromolecule according to the present invention, the duration of contrast enhancement has been significantly improved in comparison to that of the current small molecular contrast media compounds containing iodine, the in vivo toxicity has been reduced by forming a protective layer with relatively long biocompatible polymer chains which prevents the exposure of the toxic iodine-containing compounds substituted near the surface of the core region to the external environment for potential adverse effects, the in vivo circulation time has been increased by preventing rapid uptake by macrophages, the excretion is realized at the adequate time point after the intravascular injection, the large-scale production at high yield and low cost is amenable due to the simple preparation and purification methods, the reproducibility in terms of the preparation and effects is high due to the relatively low polydispersity, and the structural integrity of the iodine-containing radial-shaped macromolecules is firmly ensured because the compound is entirely formed by covalent bonds. Therefore, the iodine-containing radial-shaped macromolecule may be suitable for the preparation of a CT contrast medium.

  本发明公开了一种适用于计算机断层扫描（CT）造影剂活性成分的含碘径向形大分子、其制备方法以及包括其在内的造影剂组合物。与目前的含碘小分子造影剂化合物相比，本发明的含碘径向形大分子造影剂的造影增强持续时间显著提高，通过形成具有相对较长的生物相容性聚合物链的保护层，降低了体内毒性，该保护层可防止核心区域表面附近被取代的有毒含碘化合物暴露于外部环境，从而避免潜在的不利影响、通过防止巨噬细胞的快速吸收，延长了体内循环时间；在血管内注射后的适当时间点实现了排泄；由于制备和纯化方法简单，可实现高产低成本的大规模生产；由于相对较低的多分散性，制备和效果的可重复性较高；由于化合物完全由共价键形成，确保了含碘径向形大分子结构的完整性。因此，该含碘放射状大分子可用于制备 CT 造影剂。
• EP2604289B1
  申请人：——

  公开号：EP2604289B1

  公开（公告）日：2017-08-16
• US9387267B2
  申请人：——

  公开号：US9387267B2

  公开（公告）日：2016-07-12
• Iodine-containing radial-shaped macromolecular compounds, preparation method thereof and contrast media compositions for CT comprising the same
  申请人：Kim Yoonkyung

  公开号：US09387267B2

  公开（公告）日：2016-07-12

  Disclosed herein is an iodine-containing radial-shaped macromolecule suitable for an active ingredient of the computed tomography (CT) contrast medium, a method to prepare the same, and a contrast medium composition including the same. With respect to the iodine-containing radial-shaped macromolecule according to the present invention, the duration of contrast enhancement has been significantly improved in comparison to that of the current small molecular contrast media compounds containing iodine.

  本文披露了一种含碘的径向形状大分子，适用于计算机断层扫描（CT）造影剂的活性成分，以及一种制备该大分子的方法和包括该大分子的造影剂组合物。就本发明的含碘径向形状大分子而言，与当前含碘小分子造影剂化合物相比，对比增强的持续时间显著提高。