(Z)-1-(benzo[d][1,3]dioxol-5-yl)-N-phenylmethanimine oxide | 95794-11-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (Z)-1-(benzo[d][1,3]dioxol-5-yl)-N-phenylmethanimine oxide
• 英文别名: 1-(1,3-benzodioxol-5-yl)-N-phenylmethanimine oxide
• CAS: 95794-11-9
• 化学式: C₁₄H₁₁NO₃
• 分子量: 241.246
• InChiKey: ZYMPIMWKBKPKIX-OQLLNIDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  47.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-1-(benzo[d][1,3]dioxol-5-yl)-N-phenylmethanimine oxide 在 三氯化铝 作用下， 以 苯 为溶剂， 反应 12.0h， 生成 (3R,3aS,6aR)-3-Benzo[1,3]dioxol-5-yl-2,5-diphenyl-tetrahydro-pyrrolo[3,4-d]isoxazole-4,6-dione
  参考文献：
  名称：

  甲亚胺N-氧化物的反应。6.路易斯酸催化的硝酮与N-苯基马来酰亚胺反应的光谱研究

  摘要：

  DOI：

  10.1021/je00044a037

文献信息

• METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS
  申请人：Srivastava Rakesh K.

  公开号：US20080214547A1

  公开（公告）日：2008-09-04

  This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be used to bind to death receptors TRAIL-R1/DR4 and/or TRAIL-R2/DR5 and induce apoptosis in cancer cells, while sparing normal cells. The invention also describes TRAIL Death Receptor Agonists/Activators (DRAs) and their uses, such as the induction of apoptosis through caspase-8 and caspase-3 activation. The present invention also describes the methods of treating cancers, such as breast, prostate, colon, pancreatic, ovarian, lung, and brain cancers, leukemia, lymphoma, multiple myeloma, and mesothelioma, using DRAs either as single-agent treatments, or in combination with other therapies.
• US7915245B2
  申请人：——

  公开号：US7915245B2

  公开（公告）日：2011-03-29
• Reaction of azomethine N-oxides. 6. Spectroscopic study of Lewis acid catalyzed reactions of nitrones with N-phenylmaleimide
  作者：Ahmed Moukhtar Nour El-Din、Abou Elfotouh El-Said Mourad、Hesham Abdel-Nabi

  DOI：10.1021/je00044a037

  日期：1986.4