[(E)-[5-(2,3-dimethyl-4-nitrophenyl)furan-2-yl]methylideneamino]urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(E)-[5-(2,3-dimethyl-4-nitrophenyl)furan-2-yl]methylideneamino]urea
• 化学式: C14H14N4O4
• 分子量: 302.29
• InChiKey: MYZJGJWHCYRXIH-FRKPEAEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release
  申请人：Rosalind Franklin University of Medicine and Science

  公开号：US10011578B2

  公开（公告）日：2018-07-03

  Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.

  本文公开了包含能够使神经元钙平衡失调正常化的化合物的方法和组合物。还公开了包含这些化合物的用于治疗神经元或神经系统疾病的方法，包括阿尔茨海默病、帕金森病、亨廷顿病、前颞叶痴呆症、皮克病、慢性创伤性脑萎缩、脑外伤、中风、小脑共济失调、多发性硬化症、唐氏综合征和衰老相关的中枢神经系统疾病。
• US20140275112A1
  申请人：——

  公开号：US20140275112A1

  公开（公告）日：2014-09-18
• Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release
  申请人：Rosalind Franklin University of Medicine and Science

  公开号：US20160024038A1

  公开（公告）日：2016-01-28

  Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.
• Compounds for Stabilizing Ryanodine Receptors from Aberrant Levels of Calcium Release
  申请人：Rosalind Franklin University of Medicine and Science

  公开号：US20180022722A1

  公开（公告）日：2018-01-25

  Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.
• US9102645B2
  申请人：——

  公开号：US9102645B2

  公开（公告）日：2015-08-11