2,4-dichloro-N-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dichloro-N-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]benzamide
• 化学式: C18H11Cl2N3O4
• 分子量: 404.2
• InChiKey: MPALXRDSKZYUMX-UFFVCSGVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS FOR STABILIZING RYANODINE RECEPTORS FROM ABERRANT LEVELS OF CALCIUM RELEASE<br/>[FR] COMPOSÉS POUR STABILISER DES RÉCEPTEURS DE RYANODINE À PARTIR DE NIVEAUX ABERRANTS DE LIBÉRATION DE CALCIUM
  申请人：UNIV ROSALIND FRANKLIN MEDICINE & SCIENCE

  公开号：WO2014144654A1

  公开（公告）日：2014-09-18

  Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.