[(E)-(2-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] benzenesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(E)-(2-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] benzenesulfonate
• 化学式: C₁₃H₁₁NO₄S
• 分子量: 277.3
• InChiKey: DZHSSEUJLOOKQQ-BUHFOSPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  81.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] P300/CBP INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS DE P300/CBP ET LEURS MÉTHODES D'UTILISATION
  申请人：UNIV FLORIDA

  公开号：WO2013148114A1

  公开（公告）日：2013-10-03

  The subject invention pertains to a class of compounds that inhibit the function of p300/CBP, GCN5 and PCAF. P300/CBP inhibition was noted to result in inhibition of tumor cell growth and killing of tumor cells. P300/CBP inhibition is, thus, useful for treatment of various types of cancers, including acute lymphoblatic leukemia (ALL), acute myelogenous leukemia (AML), acute promyelocytic leukemia, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute monocytic leukemia (AMOL), hairy cell leukemia, large cell immunoblastic lymphoma, plasmacytoma, multiple myeloma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, leukemia, brain cancer, lung cancer, central nervous system (CNS) cancer, melanoma, renal cancer, prostate cancer, colon cancer, ovarian cancer and breast cancer. The compounds disclosed herein can be used alone or in combination with other cancer treatment regimens (e.g., radiation therapy and/or other chemotherapeutic agents that are administered to a subject having a tumor, cancer or neoplasia).