4-chlorophenyl(4-methylpiperidin-1-yl)methanone | 313966-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chlorophenyl(4-methylpiperidin-1-yl)methanone
• 英文别名: 1-(4-Chlorobenzoyl)-4-methylpiperidine；(4-chlorophenyl)-(4-methylpiperidin-1-yl)methanone
• CAS: 313966-13-1
• 化学式: C₁₃H₁₆ClNO
• mdl: MFCD00783638
• 分子量: 237.729
• InChiKey: LCCVBEBLQYNZHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-甲基哌啶 、 4-氯苯甲醛 在 potassium tetrachloroaurate(III) 、 potassium carbonate 作用下， 以 水 、 乙腈 为溶剂， 反应 12.0h， 以50%的产率得到4-chlorophenyl(4-methylpiperidin-1-yl)methanone
  参考文献：
  名称：

  在水性介质中由醛和胺合成金催化的酰胺。

  摘要：

  在温和的反应条件下，由醛和胺在水性介质中有效合成金催化的酰胺已得到开发。

  DOI：

  10.1039/c2cc17689k

文献信息

• N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS
  申请人：Elmore Steven W.

  公开号：US20100035879A1

  公开（公告）日：2010-02-11

  Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有公式的化合物是凋亡促进剂。还公开了制备这些化合物的方法、含有这些化合物的组合物以及使用这些化合物的治疗方法。
• Carbostyril compound
  申请人：Kuroda Takeshi

  公开号：US20070179173A1

  公开（公告）日：2007-08-02

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R 4 and R 5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R 1 is a hydrogen atom, etc; R 2 is a hydrogen atom, etc; and R 3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的碳基噻吩化合物或其盐，其中A是直接键，较低的烷基烷基或较低的烷基亚烷基；X是氧原子或硫原子；R4和R5分别表示氢原子；碳基噻吩骨架的3和4位之间的键是单键或双键；R1是氢原子等；R2是氢原子等；R3是氢原子等。本发明的碳基噻吩化合物或其盐能够诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和伤口等疾病。
• N-SULFONYLUREA APOPTOSIS PROMOTERS
  申请人：Elmore Steven W.

  公开号：US20080146572A1

  公开（公告）日：2008-06-19

  Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有以下化学式的化合物是凋亡促进剂。还公开了制备这些化合物的方法，含有这些化合物的组合物以及使用这些化合物进行治疗的方法。
• CARBOSTYRIL COMPOUND
  申请人：Kuroda Takeshi

  公开号：US20100261705A1

  公开（公告）日：2010-10-14

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R 4 and R 5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R 1 is a hydrogen atom, etc; R 2 is a hydrogen atom, etc; and R 3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的羧基苯基咔唑化合物或其盐，其中A表示直接键，较低的烷基烷基或较低的烷基亚甲基烷基；X表示氧原子或硫原子；R4和R5各代表氢原子；羧基苯基咔唑骨架的3和4位置之间的键是单键或双键；R1是氢原子等；R2是氢原子等；R3是氢原子等。本发明的羧基苯基咔唑化合物或其盐可诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和创伤等疾病。
• Nitrogen-containing compounds and pharmaceutical compositions thereof for the treatment of atrial fibrillation
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP2746272A1

  公开（公告）日：2014-06-25

  The present invention provides a novel amino compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to an amino compound represented by General Formula (1): or a salt thereof, wherein R1 and R2 are each independently hydrogen or organic group; XA and XB are each independently a bond, alkylene, alkenylene, -CO-, -SO2-, or -CONH-, wherein each of the alkylene and alkenylene chains can optionally contain one or more substituents selected from the group consisting of -S-, -C(=S)-, -SO2-, -CO-, -O-, -NH-, -CONH- and -SO2NH-, and the hydrogen atom (H) bonded to the nitrogen atom (N) in XA and XB is optionnally substituted with a subsituent selected from the group consisting of lower alkyl, phenyl lower alkyl and phenyl; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; R3 is (i) a heterocyclic group which is optionally substituted with one or more substituents, or (ii) an aryl group substituted with one or more substituents select from the group consisting of oxo, lower alkyl, carboxyl, halo-lower alkyl, lower alkanoyl lower alkyl, phenyl lower alkyl, cyclo lower alkyl, lower alkoxy, halo lower alkoxy, phenyl lower alkoxy, phenoxy, cyano, hydroxyl, halogen, nitro, lower alkylthio, lower alkanoyl, lower alkoxy carbonyl, lower alkenyl, phenyl, triazolyl, isoxazolyl, imidazolyl, pyrrolyl, benzo[d]oxazolyl, benzo[d]thiazolyl and the group represented by General Formula (2): wherein Y is a bond, lower alkylene, or -CO-; R4 and R5 are each independently hydrogen, lower alkyl, cyclo lower alkyl, phenyl, or lower alkanoyl; or R4 and R5 may be linked to form a ring together with the neighboring nitrogen, and the ring may optionally have one or more substituents.

  本发明提供了一种新型氨基化合物，它能比其他 K+ 通道更有效、更有选择性地阻断 IKur 电流或 Kv1.5 通道。本发明涉及一种由通式（1）表示的氨基化合物： 或其盐、 其中 R1 和 R2 各自独立地为氢或有机基团； XA和XB各自独立地为键、亚烷基、亚烯基、-CO-、-SO2-或-CONH-，其中每个亚烷基和亚烯基链可任选地包含一个或多个选自-S-、-C(＝S)-、-SO2-、-CO-、-O-、-NH-、-CONH-和-SO2NH-，并且与 XA 和 XB 中的氮原子（N）结合的氢原子（H）可任选被选自低 级烷基、苯基低级烷基和苯基组成的组的取代基取代； A1 是低级亚烷基，可任选被选自羟基和氧代的一个或多个取代基取代； R3 是 (i) 可任选被一个或多个取代基取代的杂环基团，或 (ii) 被一个或多个取代基取代的芳基，取代基选自以下组成的基团：氧代、低级烷基、羧基、卤代低级烷基、低级烷酰基、苯基低级烷基、环低级烷基、低级烷氧基、卤代低级烷氧基、苯基低级烷氧基、苯氧基、氰基、羟基、卤素、硝基、低级烷硫基、低级烷酰基、低级烷氧羰基、低级烷氧基羰基、低级烷氧基烷基、低级烷氧基羰基、低级烷氧基烷基、低级烷氧基烷基、低级烷氧基羰基、 低级烷氧基羰基、低级烯基、苯基、三唑基、异噁唑基、咪唑基、吡咯基、苯并[d]恶唑基、 苯并[d]噻唑基和通式 (2) 所代表的基团： 其中 Y 是键、低级亚烷基或 -CO-；R4 和 R5 各自独立地是氢、低级烷基、环低级烷基、苯基或低级烷酰基；或者 R4 和 R5 可与邻近的氮连接在一起形成环，该环可任选具有一个或多个取代基。