[(E)-1-phenylpropan-2-ylideneamino] acetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(E)-1-phenylpropan-2-ylideneamino] acetate
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: UVLYVQLNTYHJSF-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [(E)-1-phenylpropan-2-ylideneamino] acetate 、 苯甲酰氯 、 三乙胺 以37%的产率得到
  参考文献：
  名称：

  NAKANISHI, SABURO;HIRANO, TAKEHIRO;OTSUJI, YOSHIO;ITOH, KEIJI, CHEM. LETT.,(1987) N 11, 2167-2168

  摘要：

  DOI：

文献信息

• [EN] ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：LUPIN LTD

  公开号：WO2013030750A1

  公开（公告）日：2013-03-07

  Compounds of the general formula (I), their tautomeric forms, their stereoisomers, their analogs, their prodrugs, their isotopes, their N-oxides, their metabolites, their pharmaceutically acceptable salts, polymorphs, solvates, optical isomers, clathrates, co-crystals, combinations with suitable medicament, pharmaceutical compositions containing them, methods of making of the above compounds, and their use as antiviral candidate, more specifically as anti-HCV are disclosed.

  本发明公开了一般式（I）的化合物，它们的互变异构体，立体异构体，类似物，前药，同位素，N-氧化物，代谢物，药学上可接受的盐，多晶体，溶剂合物，光学异构体，笼合物，与适当药物的组合，含有它们的制药组合物，上述化合物的制备方法，以及它们作为抗病毒候选物，更具体地作为抗HCV的用途。
• Chelation directed C—H activation reactions catalyzed by solid-supported palladium(II) catalysts
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US10000453B2

  公开（公告）日：2018-06-19

  Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions are used to directly and regioselectively or regiospecifically functionalize specific C—H bonds, e.g. to build complexity into small molecules. Features and advantages of the present invention will be set forth in the description of invention that follows, and in part will be apparent from the description or may be learned by practice of the invention. The invention will be realized and attained by the compositions and methods particularly pointed out in the written description and claims hereof.

  提供了在多壁碳纳米管 (MWCNT)、单壁碳纳米管 (SWCNT) 或石墨烯上由 Pd(11) 催化的螯合定向 C-H 活化反应。这些反应可用于直接、区域选择性或区域特异性地官能化特定的 C-H 键，例如将复杂性转化为小分子。本发明的特征和优点将在下文的发明描述中阐述，部分特征和优点将从描述中显而易见，或可通过本发明的实践了解到。本发明将通过书面说明和权利要求中特别指出的组合物和方法来实现和达到。
• CHELATION DIRECTED C-H ACTIVATION REACTIONS CATALYZED BY SOLID-SUPPORTED PALLADIUM(II) CATALYSTS
  申请人：Virginia Commonwealth University

  公开号：EP3227018B1

  公开（公告）日：2021-06-30