5-Piperonylidene-2-thio-2,4-oxazolidinedione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 5-Piperonylidene-2-thio-2,4-oxazolidinedione
• 英文别名: (5E)-5-(1,3-benzodioxol-5-ylmethylidene)-2-sulfanylidene-1,3-oxazolidin-4-one
• 化学式: C₁₁H₇NO₄S
• 分子量: 249.24
• InChiKey: DFFPBCGZNPJKGW-RUDMXATFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  88.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] OXAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS<br/>[FR] DERIVES D'OXAZOLIDINE UTILES POUR LE TRAITEMENT ET LA PREVENTION DE TROUBLES METABOLIQUES DES OS
  申请人：ROCHE DIAGNOSTICS GMBH

  公开号：WO2000018745A1

  公开（公告）日：2000-04-06

  The object of the present invention are compounds of general formula (I), in which: m signifies a number between 0-8; q signifies 0-8; A signifies a single or double bond; R1 signifies hydrogen or -(CH2)a-COR4 with a =0-6, preferably 1-3; R2,R3 signify hydrogen or lower alkyl, whereby R2 and R3 can be the same or different and, when m signifies 2-8, R2 and R3 in the group CR2=CR3 can have various significances within the following sequence; R4 signifies hydroxyl, lower alkoxy or the NR1R2 residue, whereby R1 and R2 can be the same or different; R5 signifies hydrogen or methyl; X signifies oxygen or sulphur; W signifies an optionally mono- or polysubstituted saturated or unsaturated mono-, bi- or tricycle which can contain one or more hetero atoms, as well as their physiologically compatible salts, esters, optically active forms, racemates, tautomers, as well as derivatives which can be metabolized in vivo to compounds of general formula (I), as well as the use of these compounds for the production of medicaments for the prophylaxis or therapy of metabolic bone disorders.