Benzene-2-acetate, 1,3-dimethoxy-5-(1-propenyl)-

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: Benzene-2-acetate, 1,3-dimethoxy-5-(1-propenyl)-
• 英文别名: [2,6-dimethoxy-4-[(E)-prop-1-enyl]phenyl] acetate
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.26
• InChiKey: QCPPTZLKHLBRND-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Microorganisms and methods for producing 2-pyrone-4,6-dicarboxylic acid and other compounds
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US11028418B2

  公开（公告）日：2021-06-08

  Recombinant microorganisms configured for enhanced production of compounds such as 2-pyrone-4,6-dicarboxylic acid (PDC) and methods of using the recombinant microorganisms for the production of these compounds. The recombinant microorganisms include one or more modifications that reduce 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) cis-trans isomerase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) methyl esterase activity, and/or vanillate/3-O-methylgallate O-demethylase activity. The recombinant microorganisms can be used to generate PDC from media comprising plant-derived phenolics, such as syringyl phenolics, guaiacyl phenolics, and p-hydroxyphenyl phenolics. The plant-derived phenolics can be derived from pretreated lignin, including depolymerized lignin or other chemically altered lignin.

  用于提高 2-吡喃酮-4,6-二羧酸（PDC）等化合物生产的重组微生物以及使用重组微生物生产这些化合物的方法。重组微生物包括一种或多种可降低 2-吡喃酮-4,6-二羧酸（PDC）水解酶活性的修饰物、4-羧基-2-羟基-6-甲氧基-6-氧代己-2、4-羧基-2-羟基-6-甲氧基-6-氧代六氢-2,4-二烯酸酯（CHMOD）顺反异构酶活性、4-羧基-2-羟基-6-甲氧基-6-氧代六氢-2,4-二烯酸酯（CHMOD）甲酯酶活性和/或香草酸酯/3-O-甲基没食子酸酯 O-脱甲基酶活性。重组微生物可用于从含有植物源酚类（如丁香基酚类、愈创木酰基酚类和对羟基苯基酚类）的培养基中生成 PDC。植物源酚类可以来自预处理过的木质素，包括解聚木质素或其他化学变化的木质素。