2-amino-5,10-dihydro-4-(4-hydroxyphenyl)-5,10-dioxo-4H-benzo[g]chromene-3-carbothioamide | 1283774-50-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 2-amino-5,10-dihydro-4-(4-hydroxyphenyl)-5,10-dioxo-4H-benzo[g]chromene-3-carbothioamide
• 英文别名: 2-amino-4-(4-hydroxyphenyl)-5,10-dioxo-4H-benzo[g]chromene-3-carbothioamide
• CAS: 1283774-50-4
• 化学式: C₂₀H₁₄N₂O₄S
• 分子量: 378.408
• InChiKey: AZEBDJYJXJAUOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  148
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-羟基-1,4-萘醌 、 2-氰基硫代乙酰胺 、 对羟基苯甲醛 在 zinc(II) chloride 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以92%的产率得到2-amino-5,10-dihydro-4-(4-hydroxyphenyl)-5,10-dioxo-4H-benzo[g]chromene-3-carbothioamide
  参考文献：
  名称：

  One-Pot Synthesis of 2-Amino-5,10-dihydro-5,10-dioxo-4-phenyl-4H-benzo[g]chromene Derivatives Catalyzed by ZnCl₂

  摘要：

  [image omitted] An efficient one-pot synthesis of 2-amino-5,10-dihydro-5,10-dioxo-4-phenyl-4H-benzo[g]chromene derivatives has been achieved by the reaction of 2-hydroxynaphthalene-1,4-dione, cyanothioacetamide, and aromaticaldehyde in EtOH at room temperature catalyzed by ZnCl2. The structures of the products were characterized by infrared, 1H NMR, mass, and elemental analysis.

  DOI：

  10.1080/00397911003642666

文献信息

• One-Pot Synthesis of 2-Amino-5,10-dihydro-5,10-dioxo-4-phenyl-4<i>H</i>-benzo[g]chromene Derivatives Catalyzed by ZnCl₂
  作者：V. Srinivas、V. Rajeswar Rao

  DOI：10.1080/00397911003642666

  日期：2011.2.28

  [image omitted] An efficient one-pot synthesis of 2-amino-5,10-dihydro-5,10-dioxo-4-phenyl-4H-benzo[g]chromene derivatives has been achieved by the reaction of 2-hydroxynaphthalene-1,4-dione, cyanothioacetamide, and aromaticaldehyde in EtOH at room temperature catalyzed by ZnCl2. The structures of the products were characterized by infrared, 1H NMR, mass, and elemental analysis.