4'-(3-Oxo-3-(4-pyridyl)-1-propenyl)acetanilide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-(3-Oxo-3-(4-pyridyl)-1-propenyl)acetanilide
• 英文别名: N-[4-[(E)-3-oxo-3-pyridin-4-ylprop-1-enyl]phenyl]acetamide
• 化学式: C₁₆H₁₄N₂O₂
• 分子量: 266.29
• InChiKey: APOPTJNIAUCFJS-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• FAMILY OF PFKFB3 INHIBITORS WITH ANTI-NEOPLASTIC ACTIVITIES
  申请人：University Of Louisville Research Foundation, Inc.

  公开号：EP2167058B1

  公开（公告）日：2015-08-12
• US8088385B2
  申请人：——

  公开号：US8088385B2

  公开（公告）日：2012-01-03
• US8557823B2
  申请人：——

  公开号：US8557823B2

  公开（公告）日：2013-10-15
• [EN] FAMILY OF PFKFB3 INHIBITORS WITH ANTI-NEOPLASTIC ACTIVITIES<br/>[FR] FAMILLE D'INHIBITEURS DE PFKFB3 À ACTIVITÉS ANTI-NÉOPLASIQUES
  申请人：UNIV LOUISVILLE RES FOUND

  公开号：WO2008156783A2

  公开（公告）日：2008-12-24

  [EN] A methods and compounds for inhibiting 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.
  [FR] L'invention concerne des méthodes et des composés pour inhiber la 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). L'invention concerne également des méthodes pour inhiber la prolifération cellulaire, traiter le cancer et cribler des composés pour déterminer leur capacité à inhiber PFKFB3.
• [EN] MEANS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS<br/>[FR] MOYEN ET PROCÉDÉS DE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS
  申请人：VIB VZW

  公开号：WO2012119949A1

  公开（公告）日：2012-09-13

  The present invention has found that inhibitors reducing the glycolytic flux can be used for treatment of neurodegenerative diseases such as Alzheimer's disease, Parkonson's disease and amyotrophic lateral sclerosis. In particular the invention provides constructs comprising siRNAs directed against PHD1 for the treatment of ALS and siRNA's directed against PFKFB3 for the treatment of neurodegenerative diseases. The invention also provides the use of a therapeutically effective amount of aza chalcones or a pharmaceutically acceptable salt thereof for the treatment of neurological diseases.