N-对甲苯磺酰基邻苯二甲酰亚胺 | 27722-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: N-对甲苯磺酰基邻苯二甲酰亚胺
• 英文名称: N-(4-methylbenzenesulphonyl)phthalimide
• 英文别名: N-(4-methylphenylsulfonyl)phthalimide；N-p-toluenesulphonylphthalimide；2-tosylisoindoline-1,3-dione；N-tosylphthalimide；N-(p-methylbenzenesulfonyl)phthalimide；N-(toluene-4-sulfonyl)-phthalimide；Phthalimide, N-(p-tolylsulfonyl)-；2-(4-methylphenyl)sulfonylisoindole-1,3-dione
• CAS: 27722-45-8
• 化学式: C₁₅H₁₁NO₄S
• mdl: MFCD00626543
• 分子量: 301.323
• InChiKey: XUOVUJLDTKFSEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  79.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2925190090

反应信息

• 作为反应物：
  描述：

  N-对甲苯磺酰基邻苯二甲酰亚胺 以50%的产率得到
  参考文献：
  名称：

  EL-SHARIEF, A. M. SH.;HASSANIN, A. A., EGYPT. J. SCI., 1982, 25, N 6, 531-540

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(toluene-4-sulfinyloxy)-phthalimide 生成 N-对甲苯磺酰基邻苯二甲酰亚胺
  参考文献：
  名称：

  Kuehle; Wegler, Justus Liebigs Annalen der Chemie, 1958, vol. 616, p. 183,206

  摘要：

  DOI：

文献信息

• Highly Efficient Preparation of Amides from Aminium Carboxylates Using N-(p-toluenesulfonyl) Imidazole
  作者：Somayeh Behrouz、Mohammad Navid Soltani Rad、Elham Forouhari

  DOI：10.3184/174751916x14531325057887

  日期：2016.2

  N-(p-toluenesulfonyl)imidazole in the presence of triethylamine in DMF at 100 °C afforded the corresponding amides in good to excellent yields. N-(p-Toluenesulfonyl)imidazole proved to be a highly efficient coupling reagent for the preparation of numerous structurally diverse primary, secondary and tertiary amides.

  在三乙胺的存在下，在 DMF 中，在 100 °C 下用 N-（对甲苯磺酰基）咪唑处理羧酸铵，得到相应的酰胺，收率良好至极好。N-（对甲苯磺酰基）咪唑被证明是一种高效的偶联剂，可用于制备多种结构不同的伯、仲和叔酰胺。
• An environmentally benign solvent/catalyst-free one-pot synthesis of N-substituted phthalimides via Aza-wittig reaction
  作者：Murugan Sathishkumar、Kulandaivel Palanikumar、Arumugam Mariappan、Sivasubramaniyan Archana、Alagusundaram Ponnuswamy

  DOI：10.1007/s13738-012-0090-7

  日期：2012.10

  For the first time an environmentally benign solvent/catalyst-free protocol for the synthesis of a variety of N-substituted phthalimides is submitted. It involves a one-pot coupling of nascent phosphazene generated in situ with phthalic anhydride. The protocol is novel in (1) avoiding toxic solvents, (2) no catalyst is employed and (3) no isophthalimide is formed as noted in the prevailing solution phase/catalysed methodology.

  本研究首次提出了一种用于合成各种 N-取代邻苯二甲酰亚胺的无害环境的无溶剂/无催化剂方案。它涉及原位生成的新生磷苯与邻苯二甲酸酐的一锅偶联。该方案的新颖之处在于：(1) 避免使用有毒溶剂；(2) 不使用催化剂；(3) 不会形成现行溶液相/催化方法中提到的间苯二甲酰亚胺。
• 3-Acyloxymethyl-cephem compounds
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04166178A1

  公开（公告）日：1979-08-28

  Novel 3-acyloxymethyl-cephem compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen or an acyl group; X is a divalent group consisting of a carbon chain having 2 to 3 carbon atoms and a carbonyl or sulfonyl group at one terminal end thereof, said divalent group being either substituted or unsubstituted on the carbon chain; and Z is an organic acid residue, and salts thereof were found to be useful as starting materials for preparing cephalosporins of the formula: ##STR2## wherein R.sup.2 stands for a residue of a nucleophilic compound and R.sup.1 has the same meaning as above.

  新型的3-酰氧甲基头孢菌素化合物的化学式如下：其中R.sup.1为氢或酰基；X为二价基团，由具有2至3个碳原子的碳链和一个端部含有羰基或磺酰基的基团组成，该二价基团在碳链上可以是取代或未取代的；Z为有机酸残基及其盐，发现它们可作为制备头孢菌素的起始材料：其中R.sup.2代表亲核化合物的残基，R.sup.1的含义与上述相同。
• Efficient<i>N</i>-acylation of sulfonamides using cesium salt of Wells–Dawson heteropolyacid as catalyst: Synthesis of new<i>N</i>-acyl sulfonamides and cyclic imides
  作者：Nesma Benali、Chafika Bougheloum、Sabrina Alioua、Robila Belghiche、Abdelrani Messalhi

  DOI：10.1080/00397911.2018.1535077

  日期：2018.12.17

  Abstract N-acylation of substituted sulfonamides with different anhydrides in the presence of Cesium salt of Wells–Dawson heteropolyacid (Cs5HP2W18O62) as an efficient and reusable catalyst was investigated for the first time. Cs5HP2W18O62 was used with a catalytic amount in water as a green solvent. At room temperature, a series of N-acylsulfonamides were synthesized, while under refluxing conditions

  摘要 首次研究了在 Wells-Dawson 杂多酸铯盐 (Cs5HP2W18O62) 存在下，取代磺酰胺与不同酸酐的 N-酰化反应，该催化剂是一种高效且可重复使用的催化剂。Cs5HP2W18O62 以催化量在水中用作绿色溶剂。在室温下合成了一系列N-酰基磺酰胺，在回流条件下得到了新的含有磺酰基的环状酰亚胺。原子经济性、高产率、易于后处理以及简单的催化剂回收和可重复使用是该过程的关键特征。图形摘要
• Two-photon absorption dye-containing material, three-dimensional refractive index modulation material, three-dimensional absorption index modulation material and three-dimensional optical recording material
  申请人：Takizawa Hiroo

  公开号：US20050019711A1

  公开（公告）日：2005-01-27

  To provide a two-photon absorption dye-containing material having a great off-resonant two-photon absorption cross section and comprising a two-photon absorption dye capable of decoloring itself through off-resonant two-photon absorption, useful for a three-dimensional refractive index or absorption index modulation material, a three-dimensional optical recording medium, three-dimensional refractive index modulation method and recording and reproducing method for a three-dimensional optical recording medium a two-photon absorption dye-containing material comprising at least a two-photon absorption dye capable of decoloring itself through two-photon absorption.

  提供一种具有较大离共振双光子吸收截面的含有双光子吸收染料的材料，包括能够通过离共振双光子吸收脱色的双光子吸收染料，适用于三维折射率或吸收率调制材料，三维光学记录介质，三维折射率调制方法以及三维光学记录介质的记录和再现方法，其中包括至少一种能够通过双光子吸收脱色的双光子吸收染料的双光子吸收染料含材料。