(NZ)-N-[(2,6-difluorophenyl)methylidene]hydroxylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (NZ)-N-[(2,6-difluorophenyl)methylidene]hydroxylamine
• 化学式: C₇H₅F₂NO
• 分子量: 157.12
• InChiKey: PGWOZJHFLGQGDU-WMZJFQQLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors
  申请人：FORUM PHARMACEUTICALS, INC.

  公开号：US20180134696A1

  公开（公告）日：2018-05-17

  The present invention relates to novel aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of Alpha7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.