N-methyl 2'-orthochlorobenzoyl-4'-chloro 2-[(2-imidazolyl)thio]acetanilide hydrochloride | 128433-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl 2'-orthochlorobenzoyl-4'-chloro 2-[(2-imidazolyl)thio]acetanilide hydrochloride
• 英文别名: N-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-(1H-imidazol-2-ylsulfanyl)-N-methylacetamide;hydron;chloride
• CAS: 128433-27-2
• 化学式: C₁₉H₁₅Cl₂N₃O₂S*ClH
• 分子量: 456.78
• InChiKey: UPYOXEDEHRFKKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.12
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  91.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-Chlor-2-methylchloracetamido-2'-chlorbenzophenon 、 2-巯基咪唑 生成 N-methyl 2'-orthochlorobenzoyl-4'-chloro 2-[(2-imidazolyl)thio]acetanilide hydrochloride
  参考文献：
  名称：

  PATOISEAU, JEAN-FRANCOIS;AUTIN, JEAN-MARIE;COUSSE, HENRI;SALES, VERONIQUE+

  摘要：

  DOI：

文献信息

• Thioformamidines, and use as medicaments
  申请人：Pierre Fabre Medicament

  公开号：US05025015A1

  公开（公告）日：1991-06-18

  Formamidine compounds of general formula I ##STR1## in which: R.sub.1 represents H or C.sub.1-4 alkyl, R.sub.2 represents benzoyl, benzyl, or alphahydroxybenzyl, the aromatic ring being optionally substituted by a halogen atom, R.sub.3 and R.sub.4, which are identical or different, represent hydrogen, lower-alkyl, or lower-alkenyl, or form between them with the formamidine function a heterocycle, R.sub.5 represents hydrogen or C.sub.1-4 lower-alkyl or forms with R.sub.4 a double bond (--N.dbd.R.sub.4) in the case of pseudoaromatic heterocycles, n equals 0 or 1, A represents a linear or branched C.sub.1-4 alkylene chain, X represents hydrogen, halogen, C.sub.1-4 lower-alkyl, C.sub.1-4 lower-alkoxy, or nitro, and pharmaceutically-acceptable salts thereof, are disclosed. The compounds and pharmaceutical compositions thereof are used, optionally in combination with other active principles, as drugs for the treatment of gastrointestinal ailments, especially as gastric antisecretory and antiulcer agents.

  一般式I的甲酰胺化合物如下：##STR1## 其中：R.sub.1代表H或C.sub.1-4烷基，R.sub.2代表苯甲酰基、苄基或α-羟基苄基，芳香环可选地被卤素原子取代，R.sub.3和R.sub.4相同或不同，代表氢、低烷基或低烯基，或者与甲酰胺基团形成杂环，R.sub.5代表氢或C.sub.1-4低烷基，或者在伪芳香杂环的情况下与R.sub.4形成双键(--N.dbd.R.sub.4)，n等于0或1，A代表线性或支链C.sub.1-4烷基链，X代表氢、卤素、C.sub.1-4低烷基、C.sub.1-4低烷氧基或硝基，以及其药学上可接受的盐。这些化合物及其制剂可用于治疗胃肠疾病，特别是作为胃抗分泌和抗溃疡剂，可选地与其他活性成分联合使用。
• Thioformamidines, their preparation and use as medicaments
  申请人：Pierre Fabre Medicament

  公开号：US05091415A1

  公开（公告）日：1992-02-25

  Formamidine compounds of general formula I ##STR1## in which: R.sub.1 represents H or C.sub.1-4 alkyl, R.sub.2 represents benzoyl, benzyl, or alpha-hydroxybenzyl, the aromatic ring being optionally substituted by a halogen atom, R.sub.3 and R.sub.4, which are identical or different, represent hydrogen, lower-alkyl, or lower-alkenyl, or form between them with the formamidine function a heterocycle, R.sub.5 represents hydrogen or C.sub.1-4 lower-alkyl or forms with R.sub.4 a double bond (--N.dbd.R.sub.4) in the case of pseudoaromatic heterocycles, n equals 0 or 1, A represents a linear or branched C.sub.1-4 alkylene chain, X represents hydrogen, halogen, C.sub.1-4 lower-alkyl, C.sub.1-4 lower-alkoxy, or nitro, and pharmaceutically-acceptable salts thereof, are disclosed. The compounds and pharmaceutical compositions thereof are used, optionally in combination with other active principles, as drugs for the treatment of gastrointestinal ailments, especially as gastric antisecretory and antiulcer agents.

  一般式为I的甲酰胺化合物##STR1##其中：R.sub.1代表H或C.sub.1-4烷基，R.sub.2代表苯甲酰基，苄基或α-羟基苄基，芳香环可选择性地被卤原子取代，R.sub.3和R.sub.4相同或不同，代表氢，低烷基或低烯基，或在它们之间与甲酰胺功能形成杂环，R.sub.5代表氢或C.sub.1-4低烷基，或在假芳香杂环的情况下与R.sub.4形成双键（--N.dbd.R.sub.4），n等于0或1，A代表线性或支链C.sub.1-4烷基链，X代表氢，卤素，C.sub.1-4低烷基，C.sub.1-4低烷氧基或硝基，以及其药学上可接受的盐。这些化合物及其制剂可选与其他活性成分组合，作为治疗胃肠疾病的药物，特别是作为胃抗分泌和抗溃疡剂。
• PATOISEAU, JEAN-FRANCOIS;AUTIN, JEAN-MARIE;COUSSE, HENRI;SALES, VERONIQUE+
  作者：PATOISEAU, JEAN-FRANCOIS、AUTIN, JEAN-MARIE、COUSSE, HENRI、SALES, VERONIQUE+

  DOI：——

  日期：——
• Thioformamidines, leur préparation et leur application en tant que médicaments
  申请人：PIERRE FABRE MEDICAMENT

  公开号：EP0358571B1

  公开（公告）日：1993-01-13