3-Methyl-5-[1-thiophen-2-yl-meth-(Z)-ylidene]-imidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-Methyl-5-[1-thiophen-2-yl-meth-(Z)-ylidene]-imidazolidine-2,4-dione
• 英文别名: (5Z)-3-methyl-5-(thiophen-2-ylmethylidene)imidazolidine-2,4-dione
• 化学式: C₉H₈N₂O₂S
• 分子量: 208.241
• InChiKey: QZFDLGDMZRGLNP-ALCCZGGFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-{1-methyl-5-oxo-4-[1-thiophen-2-yl-meth-(Z)-ylidene]-4,5-dihydro-1H-imidazol-2-ylsulfanyl}-tetrahydro-pyran-3-yl ester 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以79%的产率得到3-Methyl-5-[1-thiophen-2-yl-meth-(Z)-ylidene]-imidazolidine-2,4-dione
  参考文献：
  名称：

  A CONVENIENT SYNTHESIS OF GLYCOSYLATED HYDANTOINS AS POTENTIAL ANTIVIRAL AGENTS

  摘要：

  Reaction of 5-arylidene-2-thiohydantoins 3a-d with glycosyl halides 4a,b under alkaline conditions gave the respective bisglycosylated derivatives 5a-h. Deacetylation with ammonia in methanol caused a change of the S-glycosyl residue and gave the N-3 glycosylated analogues 7a-h. S-Glycosylation also occured when N-3 substituted hydantoins 9a-h were reacted.

  DOI：

  10.1080/10426509708043491