N-油基吡咯烷酮 | 69494-15-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: N-油基吡咯烷酮
• 中文别名: 1-(9-十八碳烯-1-基)-2-吡咯烷酮
• 英文名称: 2-Pyrrolidinone, 1-(9Z)-9-octadecenyl-
• 英文别名: 1-octadec-9-enylpyrrolidin-2-one
• CAS: 69494-15-1
• 化学式: C₂₂H₄₁NO
• 分子量: 335.6
• InChiKey: FUJGBKOREIZSDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Penetration enhancement with multi-component system of N-aliphatic pyrrolidones with lower alcohols
  申请人：THERATECH, INC.

  公开号：EP0491076A1

  公开（公告）日：1992-06-24

  Penetration-enhancing pharmaceutical compositions for topical transepidermal and percutaneous application are disclosed which are non-irritating to the skin. These compositions are made up of a safe and effective amount of an active pharmaceutical permeant, including hydrophilic salt forms, contained in a novel penetration-enhancing vehicle comprising, (1) 0.01 to 20% w. of an N-aliphatic pyrrolidone, wherein the aliphatic portion is a C₈ to C₂₂ alkyl or alkenyl chain which can be a straight or branched; (ii) 5-75% w. of a lower alkanol selected from the group consisting of ethanol, propanol and isopropanol and mixtures thereof; (iii) 5.0 to 94.99% w. an inert carrier such as water and (iv) 0 to 20% w. of a cell-envelope disordering compound, such as methyl laurate, glycerol monolaurate, oleic acid, oleyl alcohol, glycerol monooleate, glycerol dioleate, glycerol trioleate and mixtures thereof. Capryl, lauryl, myristoleyl and oleyl pyrrolidones are exemplary of the N-alkyl or alkenyl pyrrolidones which may be utilized. The compositions may be administered to humans or warm-blooded animals by being applied directly to the skin or, preferably, administered in the form of a sustained release device such as a patch.

  本发明公开了对皮肤无刺激的局部经皮和经皮应用的渗透增强药物组合物。这些组合物由安全有效量的活性药物渗透剂（包括亲水盐形式）组成，包含在新型渗透增强载体中，该载体包括：(1) 0.01% 至 20% w. 的 N-脂肪族吡咯烷酮，其中脂肪族部分是 C₈ 至 C₂₂ 烷基或烯基链条，可以是直链或支链；(2) 5-75% w. 的低级烷醇，该低级烷醇选自由乙醇组成的组。(iii) 5.0 至 94.99% w.的惰性载体，如水，以及 (iv) 0 至 20% w.的细胞包膜紊乱化合物，如月桂酸甲酯、单月桂酸甘油酯、油酸、油醇、单油酸甘油酯、二油酸甘油酯、三油酸甘油酯及其混合物。辛烷基、月桂基、肉豆蔻烯基和油基吡咯烷酮是可使用的 N-烷基或烯基吡咯烷酮的范例。本发明的组合物可以直接涂抹在皮肤上或以贴片等缓释装置的形式给人或温血动物使用。
• EP0846662A2
  申请人：——

  公开号：EP0846662A2

  公开（公告）日：1998-06-10
• TYRE FOR VEHICLE WHEELS
  申请人：Pirelli Tyre S.P.A.

  公开号：EP2629987A1

  公开（公告）日：2013-08-28
• PVC COMPOSITIONS
  申请人：Kaytan Hasan

  公开号：US20100216919A1

  公开（公告）日：2010-08-26

  A PVC composition comprising PVC and a C 4 -C 30 alkyl pyrrolidone additive present in an amount of 0.1 to 20 phr sufficient to improve PVC processing or treatment compared to a control composition without said additive.
• US6124365A
  申请人：——

  公开号：US6124365A

  公开（公告）日：2000-09-26