(R)-1-acryloylpyrrolidine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (R)-1-acryloylpyrrolidine-3-carboxylic acid
• 英文别名: (3R)-1-prop-2-enoylpyrrolidine-3-carboxylic acid
• 化学式: C₈H₁₁NO₃
• 分子量: 169.18
• InChiKey: WAQCGNDULBMNQJ-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE
  申请人：The University of Nottingham

  公开号：US20200247824A1

  公开（公告）日：2020-08-06

  This invention related to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by the CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular, the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R 1a , R 2 , R 3 , R 4a , R 4b and R 4c are as defined herein.