N-环丙基-3-氨基吡咯烷 | 1228458-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: N-环丙基-3-氨基吡咯烷
• 英文名称: N-Cyclopropylpyrrolidin-3-amine
• CAS: 1228458-66-9
• 化学式: C₇H₁₄N₂
• mdl: MFCD18278203
• 分子量: 126.2
• InChiKey: DIYAZAUDWLXIIE-UHFFFAOYSA-N

物化性质

• 沸点：
  204℃
• 密度：
  1.02
• 闪点：
  93℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] QUINOLONE ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTERIENS A LA QUINOLONE
  申请人：WARNER LAMBERT CO

  公开号：WO2005049602A1

  公开（公告）日：2005-06-02

  Compounds of formula (I) wherein A is formula (II), formula (III) or formula (IV), and B is formula (V), formula (VI), or formula (VII), can be used in a variety of applications including use as antibacterial agents.

  式(I)的化合物中，其中A是式(II)，式(III)或式(IV)，B是式(V)，式(VI)或式(VII)，可用于各种应用，包括用作抗菌剂。
• Procedure for the preparation of N-cyclopropyl-4-fluoroanilines
  申请人：CENTRO MARGA PARA LA INVESTIGACION S.A.

  公开号：EP0430847A1

  公开（公告）日：1991-06-05

  Procedure for the preparation of N-cyclopropyl-4-fluoroanilines of formula I. By selective reaction of II with cyclopropylamine, piperazines or pyrrolidines, III is obtained. Its acetylation and reduction yields IV which by de-amination leads to I. R¹ is hydrogen, chlorine or methyl; R², hydrogen, halogen, methyl, a piperazinyl or a pyrroledinyl; R³, hydrogen, halogen, hydroxyl or trifluoromethyl; and R⁴, hydrogen, nitro, hydroxyl or amino. The compounds of formula I are of interest on account of their application to the preparation of quinolone group antibiotics.

  制备式I的N-环丙基-4-氟苯胺的过程。通过将II与环丙基胺、哌嗪或吡咯烷选择性反应，得到III。对其进行乙酰化和还原得到IV，再经去氨基化得到I。其中，R¹为氢、氯或甲基；R²为氢、卤素、甲基、哌嗪基或吡咯烷基；R³为氢、卤素、羟基或三氟甲基；R⁴为氢、硝基、羟基或氨基。式I的化合物因其在喹诺酮类抗生素制备中的应用而备受关注。
• LSD1 INHIBITORS AND USES THEREOF
  申请人：Constellation Pharmaceuticals, Inc.

  公开号：EP3286172B1

  公开（公告）日：2019-06-12
• HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
  申请人：CHDI Foundation, Inc.

  公开号：US20220409615A1

  公开（公告）日：2022-12-29

  Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
• [EN] METHOD FOR SYNTHESIS OF 8-ALKOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE 8-ALKOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES
  申请人：ACHILLION PHARMACEUTICALS INC

  公开号：WO2008021491A2

  公开（公告）日：2008-02-21

  [EN] The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4- b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A. The substituents R, R5, Re, R7, Rg and R9 are defined herein. The invention also provides novel synthetic intermediates useful in the synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4- diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones.
  [FR] Synthèse de 8-méthoxy-9H-isothiazolo[5,4- b]quinoline-3,4-diones et de 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones de formule A. Les substituants R, R5, Re, R7, Rg et R9 sont tels que définis dans la description. Également, nouveaux intermédiaires synthétiques utiles dans la synthèse de 8-méthoxy-9H-isothiazolo[5,4-b]quinoline-3,4- diones et de 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones.