2-(2-(dimethylamino)ethyl)-6-(propylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione | 1000288-20-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-(2-(dimethylamino)ethyl)-6-(propylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione
• 英文别名: 6-propylamino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione；2-[2-(Dimethylamino)ethyl]-6-(propylamino)benzo[de]isoquinoline-1,3-dione
• CAS: 1000288-20-9
• 化学式: C₁₉H₂₃N₃O₂
• 分子量: 325.411
• InChiKey: XVXLJOSYTZJJHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-硝基-1,8-萘醛酸酐 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 2-(2-(dimethylamino)ethyl)-6-(propylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione
  参考文献：
  名称：

  [EN] ANTI-CANCER COMPOUNDS
  [FR] COMPOSÉS ANTICANCÉREUX

  摘要：

  公开号：

  WO2009089537A3

文献信息

• A polarity-responsive lysosomes-nucleus translocation probe for the dual-emissive visualization of cell apoptosis
  作者：Tianyu Li、Chun Dai、Qingqing Lu、Minggang Tian

  DOI：10.1016/j.saa.2024.124272

  日期：2024.7

  dual-color visualization of cell apoptosis. NA-S was designed to be polarity sensitive, bearing alkalescence group, and with DNA affinity. In living cells, NA-S targeted the lysosomes to give blue fluorescence, which translocated into the nucleus during cell apoptosis to give green emission. Thereby, the cell apoptosis could be visualized with NA-S in dual-emissive manner. With the unique probe, the cell

  细胞凋亡的可视化是一项关键任务，在生物学、病理学和生物医学的基础研究中起着核心作用。双发射荧光探针是研究细胞凋亡的理想分子工具，但很少报道。在此，利用溶酶体和细胞核之间的极性差异，开发了一种易位型荧光探针 （NA-S） 用于细胞凋亡的双色可视化。NA-S 被设计为极性敏感，带有碱性基团，并具有 DNA 亲和力。在活细胞中，NA-S 靶向溶酶体产生蓝色荧光，蓝色荧光在细胞凋亡过程中转位到细胞核中，发出绿色发射。因此，细胞凋亡可以用 NA-S 以双发射方式可视化。使用独特的探针，已成功观察到氧化应激、紫外线照射、鱼藤酮、秋水仙碱和紫杉醇诱导的细胞凋亡。
• ANTI-CANCER COMPOUNDS
  申请人：Huang Sui

  公开号：US20100303719A1

  公开（公告）日：2010-12-02

  The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
• COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS
  申请人：BROWN Dennis M.

  公开号：US20160067241A1

  公开（公告）日：2016-03-10

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to naphthalimides such as amonafide or analogs, derivatives, or prodrugs thereof.
• US8420665B2
  申请人：——

  公开号：US8420665B2

  公开（公告）日：2013-04-16
• US8829025B2
  申请人：——

  公开号：US8829025B2

  公开（公告）日：2014-09-09