Mono(glucosyluronic acid)bilirubin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: Mono(glucosyluronic acid)bilirubin
• 英文别名: (2S,3S,4S,5R,6S)-6-[3-[2-[[3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(E)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoyloxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
• 化学式: C₃₉H₄₄N₄O₁₂
• 分子量: 760.8
• InChiKey: ARBDURHEPGRPSR-GEADQAOESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  55
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  261
• 氢给体数：
  9
• 氢受体数：
  12

文献信息

• METABOLITES OF BICTEGRAVIR
  申请人：Gilead Sciences, Inc.

  公开号：US20190224206A1

  公开（公告）日：2019-07-25

  The present invention provides metabolites of the antiviral drug bictegravir, including compositions and salts thereof, which are useful in the prevention and/or treatment of HIV as well as analytical methods related to the administration of bictegravir.

  本发明提供了抗病毒药物比克特格韦的代谢产物，包括其组合物和盐，这些代谢产物在预防和/或治疗HIV方面非常有用，同时还提供了与比克特格韦的给药相关的分析方法。
• Metabolites of bictegravir
  申请人：Gilead Sciences, Inc.

  公开号：US11253524B2

  公开（公告）日：2022-02-22

  The present invention provides metabolites of the antiviral drug bictegravir, including compositions and salts thereof, which are useful in the prevention and/or treatment of HIV as well as analytical methods related to the administration of bictegravir.

  本发明提供了抗病毒药物比特拉韦的代谢物，包括其组合物和盐类，可用于预防和/或治疗艾滋病毒，以及与比特拉韦用药相关的分析方法。
• PROCESS FOR MANUFACTURING A PUPPY PAD
  申请人：7905122 Canada Inc.

  公开号：EP3436813B1

  公开（公告）日：2022-07-20
• METABOLIC PROFILING WITH MAGNETIC RESONANCE MASS SPECTROMETRY (MRMS)
  申请人：Oregon Institute of Science and Medicine

  公开号：US20190391092A1

  公开（公告）日：2019-12-26

  A method for constructing a metabolic profile of a mammalian (such as a human) subject from one of more urine samples from the subject uses magnetic resonance mass spectrometry (MRMS) for the rapid and inexpensive quantitative measurement of at least 4,000 urinary chemical substances in a single analysis. The method for metabolic profiling measures thousands of urinary substances in a urine sample from a mammalian subject in a single assay. Many of these substances can be of mammalian metabolic origin. The measurements of types and amounts of urinary substances can be correlated to assessments of present or future health of the subject.
• [EN] METABOLITES OF BICTEGRAVIR<br/>[FR] MÉTABOLITES DU BICTÉGRAVIR
  申请人：GILEAD SCIENCES INC

  公开号：WO2019144015A1

  公开（公告）日：2019-07-25

  The present invention provides metabolites of the antiviral drug bictegravir, including compositions and salts thereof, which are useful in the prevention and/or treatment of HIV as well as analytical methods related to the administration of bictegravir.