13alpha-Hydroxyspartein-2-one

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 英文名称: 13alpha-Hydroxyspartein-2-one
• 英文别名: (1R,2R,9R,10R,12S)-12-hydroxy-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecan-6-one
• 化学式: C₁₅H₂₄N₂O₂
• 分子量: 264.36
• InChiKey: JVYKIBAJVKEZSQ-RKQHYHRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHOD FOR THE DETERMINATION OF PROCESSING INFLUENCES ON THE ENERGY VALUE OF FEEDSTUFF RAW MATERIALS AND/OR FEEDSTUFFS
  申请人：Evonik Degussa GmbH

  公开号：EP3567596A1

  公开（公告）日：2019-11-13

  The present invention relates to computer-implemented methods for the determination and/or assessment of processing influences on the energy value of a feedstuff raw material and/or feedstuff, in which the processing conditions indicator of the feedstuff raw material and/or feedstuff is determined and the corrected energy values of the feedstuff raw material and/or feedstuff is determined. The present invention also relates to a process for the preparation of a feed considering the determined processing influences and the energy values of feedstuff raw materials and/or feedstuffs.

  本发明涉及用于确定和/或评估加工对饲料原料和/或饲料能值影响的计算机实施方法，其中确定了饲料原料和/或饲料的加工条件指标，并确定了饲料原料和/或饲料的修正能值。本发明还涉及一种考虑到确定的加工影响因素和饲料原料和/或饲料的能量值的饲料制备工艺。
• METHOD FOR THE DETERMINATION OF PROCESSING INFLUENCES ON THE NUTRITIONAL VALUE OF FEEDSTUFF RAW MATERIALS
  申请人：Evonik Operations GmbH

  公开号：EP3361248B1

  公开（公告）日：2019-12-18
• PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20200087399A1

  公开（公告）日：2020-03-19

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.
• METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20210317407A1

  公开（公告）日：2021-10-14

  Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.
• TASTE-MASKED DOSAGE FORMS
  申请人：MSB Holdings, Inc

  公开号：US20210346385A1

  公开（公告）日：2021-11-11

  Sublingual dosage forms comprising a bitter active ingredient (including sildenafil, tadalafil, tetrahydrocannabinol, and cannabidiol) and a bitterness reducing agent are described. Methods of treating sexual dysfunction by administering the sublingual dosage form to an individual in need thereof are also described.