Hydroxy-(4-methylphenyl)-oxoazanium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Hydroxy-(4-methylphenyl)-oxoazanium
• 化学式: C7H8NO2+
• 分子量: 138.14
• InChiKey: VULZRFBCQIAMJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  40.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Biphenyl compound or salt thereof
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US10723742B2

  公开（公告）日：2020-07-28

  A compound or a salt thereof represented by Formula (I). An LSD1 inhibitor containing the compound or a salt thereof as an active ingredient. A pharmaceutical composition containing the compound or salt thereof. An antitumor agent containing the compound or a salt thereof as an active ingredient.

  由式（I）代表的化合物或其盐。以该化合物或其盐为活性成分的 LSD1 抑制剂。含有该化合物或其盐的药物组合物。一种含有该化合物或其盐作为活性成分的抗肿瘤剂。
• TETRACYCLIC CARBOLINE DERATIVES FOR INHIBITING ANGIOGENESIS
  申请人：PTC Therapeutics, Inc.

  公开号：EP1732543B1

  公开（公告）日：2017-05-10
• Inhibitors Targeting the DNA-Binding Domain of Human STAT3 for Treatment of Metastatic Cancers
  申请人：Zhang Jian-Ting

  公开号：US20150094353A1

  公开（公告）日：2015-04-02

  The present invention provides STAT3 inhibitors which preferentially suppress proliferation of cancer over non-cancer cells and inhibit migration and invasion of malignant cells. The inhibitors of the present invention selectively inhibit STAT3 binding to DNA without affecting the activation and dimerization of STAT3. Furthermore, the inhibitors of the present invention inhibit expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.
• NOVEL BIPHENYL COMPOUND OR SALT THEREOF
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20210179634A1

  公开（公告）日：2021-06-17

  The present invention provides a compound represented by Formula (I) or a salt thereof; an LSD1 inhibitor that contains the compound or a salt thereof as an active ingredient; a pharmaceutical composition that contains the compound or a salt thereof; and an antitumor agent that contains the compound or a salt thereof as an active ingredient.
• US7244847B2
  申请人：——

  公开号：US7244847B2

  公开（公告）日：2007-07-17

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