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    —— (6R)-6-N-cyclopentyl-2-N-[3-(diethylamino)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H36N6O3
    (6R)-6-N-cyclopentyl-2-N-[3-(diethylamino)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-2-N-[2-(dimethylamino)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C19H30N6O3
    (6S)-6-N-cyclopentyl-2-N-[2-(dimethylamino)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2S)-2-phenylpropyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H31N5O3
    (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2S)-2-phenylpropyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[[(2S)-oxolan-2-yl]methyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C20H29N5O4
    (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[[(2S)-oxolan-2-yl]methyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(4-propan-2-yloxyphenyl)methyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H33N5O4
    (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(4-propan-2-yloxyphenyl)methyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-(2-morpholin-4-ylethyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C21H32N6O4
    (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-(2-morpholin-4-ylethyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-[(3-methylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H29N5O3
    (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-[(3-methylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2R)-4-phenylbutan-2-yl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H33N5O3
    (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2R)-4-phenylbutan-2-yl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-2-N-[(2-methylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H29N5O3
    (6S)-6-N-cyclopentyl-5,6-dimethyl-2-N-[(2-methylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclohexyl-5,6-dimethyl-2-N-[(5-methylfuran-2-yl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H29N5O4
    (6S)-6-N-cyclohexyl-5,6-dimethyl-2-N-[(5-methylfuran-2-yl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-[(2-methylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H29N5O3
    (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-[(2-methylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-N-cyclopentyl-2-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide —— C27H36N6O3
    (6R)-N-cyclopentyl-2-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide
    —— (6S)-6-N-cycloheptyl-5,6-dimethyl-2-N-[2-(4-methylphenyl)ethyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C26H35N5O3
    (6S)-6-N-cycloheptyl-5,6-dimethyl-2-N-[2-(4-methylphenyl)ethyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cycloheptyl-5,6-dimethyl-4-oxo-2-N-(pyridin-3-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H30N6O3
    (6S)-6-N-cycloheptyl-5,6-dimethyl-4-oxo-2-N-(pyridin-3-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-N-cyclopentyl-5,6-dimethyl-2-(4-methylpiperidine-1-carbonyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide —— C21H31N5O3
    (6R)-N-cyclopentyl-5,6-dimethyl-2-(4-methylpiperidine-1-carbonyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2S)-2-phenylpropyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H31N5O3
    (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2S)-2-phenylpropyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-2-N-[(2-ethoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H31N5O4
    (6R)-6-N-cyclopentyl-2-N-[(2-ethoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cycloheptyl-5,6-dimethyl-2-N-[2-(4-methylphenyl)ethyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C26H35N5O3
    (6R)-6-N-cycloheptyl-5,6-dimethyl-2-N-[2-(4-methylphenyl)ethyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cycloheptyl-2-N-(3-fluorophenyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H28FN5O3
    (6R)-6-N-cycloheptyl-2-N-(3-fluorophenyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[[(2S)-oxolan-2-yl]methyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C20H29N5O4
    (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[[(2S)-oxolan-2-yl]methyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-(2-phenylethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H29N5O3
    (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-(2-phenylethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclohexyl-2-N-[2-(dimethylamino)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C20H32N6O3
    (6S)-6-N-cyclohexyl-2-N-[2-(dimethylamino)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-N-cyclopentyl-2-[4-(2-fluorophenyl)piperazine-1-carbonyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide —— C25H31FN6O3
    (6R)-N-cyclopentyl-2-[4-(2-fluorophenyl)piperazine-1-carbonyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide
    —— (6R)-6-N-cyclohexyl-2-N-(3-fluorophenyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H26FN5O3
    (6R)-6-N-cyclohexyl-2-N-(3-fluorophenyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2R)-2-phenylpropyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H31N5O3
    (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2R)-2-phenylpropyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-2-N-[(4-ethylphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H31N5O3
    (6S)-6-N-cyclopentyl-2-N-[(4-ethylphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-2-N-[3-(4-ethylpiperazin-1-yl)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H39N7O3
    (6S)-6-N-cyclopentyl-2-N-[3-(4-ethylpiperazin-1-yl)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-2-N-[3-(diethylamino)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H36N6O3
    (6S)-6-N-cyclopentyl-2-N-[3-(diethylamino)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-2-N-[(2-methoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H29N5O4
    (6R)-6-N-cyclopentyl-2-N-[(2-methoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— 6-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C17H12Cl2N4OS
    6-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— (6R)-6-N-cyclopentyl-2-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H26FN5O3
    (6R)-6-N-cyclopentyl-2-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— 6-(3,4-dichlorophenyl)-3-(4-methylphenyl)-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C17H12Cl2N4S
    6-(3,4-dichlorophenyl)-3-(4-methylphenyl)-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— (6S)-6-N-cyclopentyl-2-N-[(3-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H26FN5O3
    (6S)-6-N-cyclopentyl-2-N-[(3-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-2-N-[3-(4-ethylpiperazin-1-yl)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H39N7O3
    (6R)-6-N-cyclopentyl-2-N-[3-(4-ethylpiperazin-1-yl)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2R)-4-phenylbutan-2-yl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H33N5O3
    (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2R)-4-phenylbutan-2-yl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(1S)-1-phenylethyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H29N5O3
    (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(1S)-1-phenylethyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— 6-(3-chloro-4-hydroxy-5-methoxyphenyl)-8-(3-chlorophenyl)-2-methyl-6a-phenyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C34H28Cl2N2O6
    6-(3-chloro-4-hydroxy-5-methoxyphenyl)-8-(3-chlorophenyl)-2-methyl-6a-phenyl-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— (6S)-N-cyclopentyl-5,6-dimethyl-2-(4-methylpiperazine-1-carbonyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide —— C20H30N6O3
    (6S)-N-cyclopentyl-5,6-dimethyl-2-(4-methylpiperazine-1-carbonyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide
    —— (6R)-6-N-cyclopentyl-2-N-[2-(4-ethoxyphenyl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H33N5O4
    (6R)-6-N-cyclopentyl-2-N-[2-(4-ethoxyphenyl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-2-N-(3-ethoxypropyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C20H31N5O4
    (6R)-6-N-cyclopentyl-2-N-(3-ethoxypropyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-2-N-benzyl-6-N-cyclohexyl-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H29N5O3
    (6S)-2-N-benzyl-6-N-cyclohexyl-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-(3-piperidin-1-ylpropyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H36N6O3
    (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-(3-piperidin-1-ylpropyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-2-N-(2-methoxyethyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C18H27N5O4
    (6R)-6-N-cyclopentyl-2-N-(2-methoxyethyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-(3-pyrrolidin-1-ylpropyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H34N6O3
    (6R)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-(3-pyrrolidin-1-ylpropyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-[(4-methylsulfanylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H29N5O3S
    (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-[(4-methylsulfanylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-(3-pyrrolidin-1-ylpropyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H34N6O3
    (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-(3-pyrrolidin-1-ylpropyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— 6-(3,4-dichlorophenyl)-3-phenyl-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C16H10Cl2N4S
    6-(3,4-dichlorophenyl)-3-phenyl-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— (6R)-N-cyclopentyl-5,6-dimethyl-2-(4-methylpiperazine-1-carbonyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide —— C20H30N6O3
    (6R)-N-cyclopentyl-5,6-dimethyl-2-(4-methylpiperazine-1-carbonyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide
    —— (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2S)-4-phenylbutan-2-yl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H33N5O3
    (6S)-6-N-cyclopentyl-5,6-dimethyl-4-oxo-2-N-[(2S)-4-phenylbutan-2-yl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-[2-(4-methylphenyl)ethyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H31N5O3
    (6R)-6-N-cyclopentyl-5,6-dimethyl-2-N-[2-(4-methylphenyl)ethyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide