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    —— (6R)-2-N-cyclopentyl-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H26FN5O3
    (6R)-2-N-cyclopentyl-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-2-N-[2-(cyclohexen-1-yl)ethyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H35N5O3
    (6R)-2-N-[2-(cyclohexen-1-yl)ethyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-2-N-[(2,5-dimethoxyphenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H33N5O5
    (6R)-2-N-[(2,5-dimethoxyphenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— 6-(3-Bromo-4-hydroxy-5-methoxyphenyl)-8-(bromomethyl)-6a,9a-dichloro-2-[2-(4-hydroxyphenyl)ethyl]-3a,4,6,10,10a,10b-hexahydroisoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C30H26Br2Cl2N2O7
    6-(3-Bromo-4-hydroxy-5-methoxyphenyl)-8-(bromomethyl)-6a,9a-dichloro-2-[2-(4-hydroxyphenyl)ethyl]-3a,4,6,10,10a,10b-hexahydroisoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— (6S)-2-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-5,6-dimethyl-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide —— C27H38N6O3
    (6S)-2-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-5,6-dimethyl-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide
    —— (6R)-6-N-benzyl-5,6-dimethyl-4-oxo-2-N-(pyridin-2-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H24N6O3
    (6R)-6-N-benzyl-5,6-dimethyl-4-oxo-2-N-(pyridin-2-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-5,6-dimethyl-4-oxo-2-N-(pyridin-2-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H24N6O3
    (6S)-6-N-benzyl-5,6-dimethyl-4-oxo-2-N-(pyridin-2-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-benzyl-5,6-dimethyl-2-N-[(4-methylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H27N5O3
    (6R)-6-N-benzyl-5,6-dimethyl-2-N-[(4-methylphenyl)methyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-2-N-(1,3-benzodioxol-5-ylmethyl)-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H24FN5O5
    (6S)-2-N-(1,3-benzodioxol-5-ylmethyl)-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-5,6-dimethyl-2-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H29N5O3
    (6S)-6-N-benzyl-5,6-dimethyl-2-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-2-N-[2-(2,4-dimethoxyphenyl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C27H31N5O5
    (6S)-6-N-benzyl-2-N-[2-(2,4-dimethoxyphenyl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-2-N-[(3-chlorophenyl)methyl]-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H23ClFN5O3
    (6R)-2-N-[(3-chlorophenyl)methyl]-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-2-N-(1,3-benzodioxol-5-ylmethyl)-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H24FN5O5
    (6R)-2-N-(1,3-benzodioxol-5-ylmethyl)-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-benzyl-2-N-[(2-ethoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C26H29N5O4
    (6R)-6-N-benzyl-2-N-[(2-ethoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-2-N-(2-methoxyethyl)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C18H29N5O4
    (6S)-2-N-(2-methoxyethyl)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-2-N-[(2,5-dimethoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C26H29N5O5
    (6S)-6-N-benzyl-2-N-[(2,5-dimethoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-2-N-[(4-ethoxy-3-methoxyphenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H35N5O5
    (6R)-2-N-[(4-ethoxy-3-methoxyphenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-(2-piperidin-1-ylethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H36N6O3
    (6S)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-(2-piperidin-1-ylethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-cycloheptyl-2-N-[(3-methoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H33N5O4
    (6R)-6-N-cycloheptyl-2-N-[(3-methoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-benzyl-5,6-dimethyl-4-oxo-2-N-(2-pyrrolidin-1-ylethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H30N6O3
    (6R)-6-N-benzyl-5,6-dimethyl-4-oxo-2-N-(2-pyrrolidin-1-ylethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-2-N-[(4-ethoxy-3-methoxyphenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H35N5O5
    (6S)-2-N-[(4-ethoxy-3-methoxyphenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-5,6-dimethyl-2-N-(3-morpholin-4-ylpropyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H32N6O4
    (6S)-6-N-benzyl-5,6-dimethyl-2-N-(3-morpholin-4-ylpropyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-5,6-dimethyl-2-N-[2-(4-methylphenyl)ethyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C26H29N5O3
    (6S)-6-N-benzyl-5,6-dimethyl-2-N-[2-(4-methylphenyl)ethyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-2-N-(3-morpholin-4-ylpropyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H31FN6O4
    (6S)-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-2-N-(3-morpholin-4-ylpropyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-2-N-(3-methoxypropyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C21H27N5O4
    (6S)-6-N-benzyl-2-N-(3-methoxypropyl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-2-N-cyclopentyl-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C20H31N5O3
    (6S)-2-N-cyclopentyl-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-(3-piperidin-1-ylpropyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H38N6O3
    (6R)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-(3-piperidin-1-ylpropyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-2-N-[(2,3-dimethoxyphenyl)methyl]-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C26H28FN5O5
    (6S)-2-N-[(2,3-dimethoxyphenyl)methyl]-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— [6-[2-[[1-Hydroxy-5-[(2-methylpropan-2-yl)oxy]-5-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-diphenyl-3a,4,5,7a-tetrahydro-1,3-benzodioxol-4-yl] 2-[3-(dimethylamino)-3-oxoprop-1-enyl]benzoate —— C46H53N3O10
    [6-[2-[[1-Hydroxy-5-[(2-methylpropan-2-yl)oxy]-5-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-diphenyl-3a,4,5,7a-tetrahydro-1,3-benzodioxol-4-yl] 2-[3-(dimethylamino)-3-oxoprop-1-enyl]benzoate
    —— (6S)-2-N-[(3-chlorophenyl)methyl]-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H23ClFN5O3
    (6S)-2-N-[(3-chlorophenyl)methyl]-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-benzyl-2-N-[2-(3,4-dimethoxyphenyl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C27H31N5O5
    (6R)-6-N-benzyl-2-N-[2-(3,4-dimethoxyphenyl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-benzyl-2-N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C29H34N6O3
    (6R)-6-N-benzyl-2-N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)propyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-(thiophen-2-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C20H27N5O3S
    (6S)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-(thiophen-2-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-2-N-ethyl-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C19H22FN5O3
    (6S)-2-N-ethyl-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-5,6-dimethyl-2-N-[3-(4-methylpiperazin-1-yl)propyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H35N7O3
    (6S)-6-N-benzyl-5,6-dimethyl-2-N-[3-(4-methylpiperazin-1-yl)propyl]-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-benzyl-2-N-(1-benzylpiperidin-4-yl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C29H34N6O3
    (6R)-6-N-benzyl-2-N-(1-benzylpiperidin-4-yl)-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-benzyl-2-N-[(4-butoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C28H33N5O4
    (6R)-6-N-benzyl-2-N-[(4-butoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— 6a,9a-Dichloro-6-(3-hydroxy-4-methoxyphenyl)-2-[2-(4-hydroxyphenyl)ethyl]-8-(2,3,4,5,6-pentafluorophenyl)-3a,4,6,10,10a,10b-hexahydroisoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C35H25Cl2F5N2O7
    6a,9a-Dichloro-6-(3-hydroxy-4-methoxyphenyl)-2-[2-(4-hydroxyphenyl)ethyl]-8-(2,3,4,5,6-pentafluorophenyl)-3a,4,6,10,10a,10b-hexahydroisoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— (6S)-2-N-[(2-chlorophenyl)methyl]-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H23ClFN5O3
    (6S)-2-N-[(2-chlorophenyl)methyl]-6-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-2-N-[2-(2-methoxyphenyl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C26H29N5O4
    (6S)-6-N-benzyl-2-N-[2-(2-methoxyphenyl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-[(1S)-1-phenylethyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H31N5O3
    (6S)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-[(1S)-1-phenylethyl]-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-2-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C22H28FN5O3
    (6S)-2-N-[(4-fluorophenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-(thiophen-2-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C20H27N5O3S
    (6R)-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-2-N-(thiophen-2-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-benzyl-5,6-dimethyl-2-N-(3-morpholin-4-ylpropyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H32N6O4
    (6R)-6-N-benzyl-5,6-dimethyl-2-N-(3-morpholin-4-ylpropyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-6-N-benzyl-2-N-[(2-methoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C25H27N5O4
    (6R)-6-N-benzyl-2-N-[(2-methoxyphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— 6a-(4-chlorophenyl)-8-(4-fluoroanilino)-6-(2-hydroxy-3-methylphenyl)-2-(4-iodophenyl)-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone —— C39H30ClFIN3O5
    6a-(4-chlorophenyl)-8-(4-fluoroanilino)-6-(2-hydroxy-3-methylphenyl)-2-(4-iodophenyl)-4,6,9a,10,10a,10b-hexahydro-3aH-isoindolo[5,6-e]isoindole-1,3,7,9-tetrone
    —— (6R)-2-N-[(2-ethoxyphenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C24H33N5O4
    (6R)-2-N-[(2-ethoxyphenyl)methyl]-5,6-dimethyl-6-N-(3-methylbutyl)-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6S)-6-N-benzyl-2-N-[(4-ethylphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C26H29N5O3
    (6S)-6-N-benzyl-2-N-[(4-ethylphenyl)methyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide
    —— (6R)-N-benzyl-5,6-dimethyl-4-oxo-2-(4-phenylpiperazine-1-carbonyl)-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide —— C27H30N6O3
    (6R)-N-benzyl-5,6-dimethyl-4-oxo-2-(4-phenylpiperazine-1-carbonyl)-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide
    —— (6R)-6-N-benzyl-2-N-[2-(furan-2-yl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide —— C23H25N5O4
    (6R)-6-N-benzyl-2-N-[2-(furan-2-yl)ethyl]-5,6-dimethyl-4-oxo-7H-pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide