2-[1-(2,7-dimethyl-8-p-tolyl-9-p-tolylimino-5,7,8,9,9a,10-hexahydro-imidazo[1,5-a]pyrimido[4,5-d]pyrimidin-7-yl)-3-hydroxy-propyl]-1,3-di-p-tolyl-isothiourea | 52073-67-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 2-[1-(2,7-dimethyl-8-p-tolyl-9-p-tolylimino-5,7,8,9,9a,10-hexahydro-imidazo[1,5-a]pyrimido[4,5-d]pyrimidin-7-yl)-3-hydroxy-propyl]-1,3-di-p-tolyl-isothiourea
• CAS: 52073-67-3
• 化学式: C₄₂H₄₆N₈OS
• 分子量: 710.946
• InChiKey: WAZKNNZQNHIEHW-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-[1-(2,7-dimethyl-8-p-tolyl-9-p-tolylimino-5,7,8,9,9a,10-hexahydro-imidazo[1,5-a]pyrimido[4,5-d]pyrimidin-7-yl)-3-hydroxy-propyl]-1,3-di-p-tolyl-isothiourea 以 甲醇 为溶剂， 生成 (3a-methyl-3-p-tolyl-tetrahydro-furo[2,3-d]thiazol-2-ylidene)-p-tolyl-amine
  参考文献：
  名称：

  Studies on Pyrimidine Derivatives and Related Compounds. LXXXIII. An Unusual Reaction of Thiamine Ylide with Diaryl Carbodiimide

  摘要：

  Reaction of thiamine with diaryl carbodiimide was found to be quite different from that of the simple thiamine model compound giving unusual (1 : 2) adduct, S- [1- (2, 7-dimethyl-8-aryl-9-arylimino-5, 7, 8, 9-tetrahydroimidazo [1, 5-a] pyrimido [4, 5-d] pyrimidin-7-yl) -3-hydroxy-propyl] -N, N'-diaryl isothioureas (IIIa, IIIb). The structure of the (1 : 2) adduct was elucidated by chemical and spectroscopic evidences, and it was found that the (1 : 2) adduct (IIIa) underwent a novel acid-catalyzed decomposition reaction to give 7-methyl-2- (N-acetyl-N, N'-di-p-tolyl) amidino-1, 4-dihydropyrimido [4, 5-d] pyrimidine (VIIIa). Mechanistic consideration on these reactions was briefly made.

  DOI：

  10.1248/cpb.22.305