trans-4-Dimethylaminocyclohexancarbonsaeure | 38605-39-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: trans-4-Dimethylaminocyclohexancarbonsaeure
• CAS: 38605-39-9
• 化学式: C₉H₁₇NO₂
• 分子量: 171.239
• InChiKey: GTUZTWPXWNPFPX-ZKCHVHJHSA-N

反应信息

• 作为产物：
  描述：

  trans-4-Dimethylamino-cyclohexyl-carbonsaeure-ethylester 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 trans-4-Dimethylaminocyclohexancarbonsaeure
  参考文献：
  名称：

  Konevenagel Reaction. Kinetic study of the reaction of (+)-3-methyl-cyclohexanone with malononitrile

  摘要：

  DOI：

  10.1021/jo00948a015

文献信息

• Pyrazolopyrimidine compound and a process for preparing the same
  申请人：Takamuro Iwao

  公开号：US20060135525A1

  公开（公告）日：2006-06-22

  The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R 2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, S02- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same.

  本发明提供了一种新型的吡唑嘧啶化合物，其化学式为[I]：其中R′为（A）取代芳基，（B）可选取代的含氮脂肪杂环基，（C）取代的环低烷基，（D）可选取代的氨基或（E）取代的杂环芳基；R2为（a）可选取代的杂环芳基或（b）可选取代的芳基；Y为单键，低碳基烷基或低碳基烯基；Z为式[II]的基团：其中Q为低碳基烷基，q为0或1的整数，或其药学上可接受的盐。该化合物具有小电导钾通道（SK通道）阻滞活性，并可作为药物使用，以及其制备方法。
• SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES
  申请人：Novartis AG

  公开号：US20130281473A1

  公开（公告）日：2013-10-24

  The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH 2 or N—R 4 and X, R 1 , R 2 , R 4 , R 6 , R 7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

  本发明涉及式(I)的取代氮含杂环的双环杂环化合物，其中Z是CH2或N-R4，X，R1，R2，R4，R6，R7和n的定义如说明书中所定义。这类化合物适用于治疗由MDM2和/或MDM4的活性或其变异体介导的疾病或疾病。
• Condensed furan compounds
  申请人：Kawaguchi Takayuki

  公开号：US20090156803A1

  公开（公告）日：2009-06-18

  The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R 3 is hydrogen or the like; and, R 4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

  本发明提供了一种公式（I）的紧凑呋喃化合物：其中环X为苯、吡啶或类似物；Y为可选取代的氨基、可选取代的环烷基、可选取代的芳基、可选取代的饱和杂环基、可选取代的不饱和杂环基；A为单键、低碳烷基、低碳烯基亚甲基、低碳烯基或氧原子；R3为氢或类似物；R4为氢、类似物或药学上可接受的盐，其作为药物特别是作为激活的血凝血酶X抑制剂非常有用。
• Benzofuran Derivatives
  申请人：Kawaguchi Takayuki

  公开号：US20090209511A1

  公开（公告）日：2009-08-20

  The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R 1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R 3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.

  本发明提供了式[1]的苯并呋喃衍生物：其中x是式：—N═或—CH═的基团；Y是可选取代的氨基基团、可选取代的环烷基团或可选取代的饱和杂环基团；A是单键、具有双键的碳链（可在链的内部或端部）或氧原子；R1是氢原子或卤原子；环B是可选取代的苯环；R3是氢原子或其药学上可接受的盐，其作为药物特别是作为激活的血凝因子X抑制剂有用。
• PYRAZOLOPYRIMIDINE COMPOUND AND PROCESS FOR PREPARING THE SAME
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1585481A2

  公开（公告）日：2005-10-19