N-(2-Morpholinoethyl)-3-(2,2,2-trifluorethoxy)-2-naphthamid | 57005-56-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-Morpholinoethyl)-3-(2,2,2-trifluorethoxy)-2-naphthamid
• 英文别名: 3-(2,2,2-trifluoro-ethoxy)-naphthalene-2-carboxylic acid 2-morpholin-4-yl-ethylamide
• CAS: 57005-56-8
• 化学式: C₁₉H₂₁F₃N₂O₃
• 分子量: 382.383
• InChiKey: OERLFBZJLHLQCF-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  N-(2-氨基乙基)吗啉 、 3-(2,2,2-trifluoro-ethoxy)-naphthalene-2-carbonyl chloride 在 三乙胺 作用下， 生成 N-(2-Morpholinoethyl)-3-(2,2,2-trifluorethoxy)-2-naphthamid
  参考文献：
  名称：

  Antiarrhythmics. N-(Aminoalkylene)trifluoroethoxybenzamides and N-(aminoalkylene)trifluoroethoxynaphthamides

  摘要：

  Benzamides and naphthamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents have been prepared and evaluated as antiarrhythmic agents in mice. Structure-action studies reveal that antiarrhythmic activity is highly dependent upon the number and position of 2,2,2-trifluoroethoxy groups. The most potent compounds are derived from 2,5-bis(2,2,2-trifluoroethoxy)benzamide, and, within this group, wide variation of the amide side chain is possible without adversely affecting the antiarrhythmic activity.

  DOI：

  10.1021/jm00245a017