4,5-dimethoxy-2-(di-n-propylamino)indan picrate | 83598-58-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4,5-dimethoxy-2-(di-n-propylamino)indan picrate
• CAS: 83598-58-7
• 化学式: C₆H₃N₃O₇*C₁₇H₂₇NO₂
• 分子量: 506.513
• InChiKey: GYZGVDIWNKIEEF-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4,5-dimethoxy-2-(di-n-propylamino)indan picrate 在 氢溴酸 作用下， 反应 3.0h， 以90%的产率得到2-Diisopropylamino-indan-4,5-diol; hydrobromide
  参考文献：
  名称：

  Conformationally restricted congeners of dopamine derived from 2-aminoindan

  摘要：

  Two series of N-substituted 2-aminoindan systems have been prepared: 4,5-dihydroxy-2-aminoindan (1) has a hydroxylation pattern analogous to the alpha conformer of dopamine, and 5,6-dihydroxy-2-aminoindan (2) has a hydroxylation pattern of the beta conformer of dopamine. All members of both series demonstrated only extremely weak binding to calf caudate homogenate. Certain N-alkylated 4,5-dihydroxyindans were violent emetics in the dog and were potent in blockade of the effect of stimulation of the cardioaccelerator nerve of the cat. In contrast, the 5,6-dihydroxy series displayed low or no activity/potency in these assays. Conformational analysis of the 2-aminoindan system is described and discussed.

  DOI：

  10.1021/jm00354a010