(4-Methyl-6-naphthalen-1-yl-pyridazin-3-yl)-(2-morpholin-4-yl-ethyl)-amine; hydrochloride | 118270-01-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4-Methyl-6-naphthalen-1-yl-pyridazin-3-yl)-(2-morpholin-4-yl-ethyl)-amine; hydrochloride
• CAS: 118270-01-2
• 化学式: C₂₁H₂₄N₄O*2ClH
• 分子量: 421.37
• InChiKey: QSHPUXARZSPURM-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  N-(2-氨基乙基)吗啉 、 3-chloro-4-methyl-6-naphthalen-1-yl-pyridazine 生成 (4-Methyl-6-naphthalen-1-yl-pyridazin-3-yl)-(2-morpholin-4-yl-ethyl)-amine; hydrochloride
  参考文献：
  名称：

  3-Aminopyridazine derivatives with atypical antidepressant, serotonergic and dopaminergic activities

  摘要：

  Minaprine [3-[(beta-morpholinoethyl)amino]-4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effects and to characterize the responsible structural requirements, a series of 47 diversely substituted analogues of minaprine were synthesized and tested for their potential antidepressant, serotonergic, and dopaminergic activities. The structure-activity relationships show that dopaminergic and serotonergic activities can be dissociated. Serotonergic activity appears to be correlated mainly with the substituent in the 4-position of the pyridazine ring whereas the dopaminergic activity appears to be dependent on the presence, or in the formation, of a para-hydroxylated aryl ring in the 6-position of the pyridazine ring.

  DOI：

  10.1021/jm00123a004