4-Hydroxy-phenylbrenztraubensaeure-semicarbazon | 936211-51-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 4-Hydroxy-phenylbrenztraubensaeure-semicarbazon
• CAS: 936211-51-7
• 化学式: C₁₀H₁₁N₃O₄
• 分子量: 237.215
• InChiKey: PYTVPKDKLOLASN-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-phenylbrenztraubensaeure-semicarbazon 在 sodium ethanolate 作用下， 以 乙二醇 为溶剂， 反应 18.0h， 以68%的产率得到5-(4-hydroxybenzyl)-6-azauracil
  参考文献：
  名称：

  Synthetic and Antiviral Studies on Certain Acyclic Nucleosides of 5-Benzyl-6-Azauracil Derivatives

  摘要：

  Several 5-(4-substituted benzyl)-6-azauracils have been synthesized from the corresponding benzaldehydes. The 5-benzyl-6-azauracils were silylated with hexamethyldisilazane and then glycosylated with aliphatic halides, e.g., (2-acetoxyethoxy)methyl bromide and 1,3-dibenzyloxy-2-chloromethoxypropane, to give protected acyclic nucleosides which were deprotected to afford acyclonucleosides of 5-(4-substituted benzyl)-6-azauracils. None of the compounds exhibited significant antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.

  DOI：

  10.1080/07328319308018563