[4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester | 175543-31-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: [4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS: 175543-31-4
• 化学式: C₄₆H₅₃NO₆Si
• 分子量: 744.015
• InChiKey: JKCGJIPJHHCKTP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  [4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 在 哌啶 、 N-甲基吗啉 、 TEA 、 氯甲酸异丁酯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 生成 6-[5-((3aR,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoic acid [4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-amide
  参考文献：
  名称：

  New non nucleosidic phosphoramidite reagent for solid phase synthesis of biotinylated oligonucleotides

  摘要：

  The synthesis of a 4-N-(6-aminohexanoyl)-4-amino-1,3-butanediol backbone functionalized with a protected biotin moiety is described. The CE phosphoramidite building block was used to incorporate the reporter group into a synthetic probe during solid phase synthesis. The ability of the modified oligomers to form DNA duplex structures with their target sequences and the stability of these structures was measured. Finally, the addition of an extra dT at the 5'-end allowed an efficient 5'-end P-32 labelling of the biotinylated oligomers.

  DOI：

  10.1016/0960-894x(95)00579-i
• 作为产物：
  描述：

  4-N-fluorenylmethyloxycarbonylamino-1,3-butanediol 在 吡啶 、 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 [4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  New non nucleosidic phosphoramidite reagent for solid phase synthesis of biotinylated oligonucleotides

  摘要：

  The synthesis of a 4-N-(6-aminohexanoyl)-4-amino-1,3-butanediol backbone functionalized with a protected biotin moiety is described. The CE phosphoramidite building block was used to incorporate the reporter group into a synthetic probe during solid phase synthesis. The ability of the modified oligomers to form DNA duplex structures with their target sequences and the stability of these structures was measured. Finally, the addition of an extra dT at the 5'-end allowed an efficient 5'-end P-32 labelling of the biotinylated oligomers.

  DOI：

  10.1016/0960-894x(95)00579-i