7,8-Dichloro-1-methyl-4,5-dihydro-1H-benzo[g]indole-2,3-dicarboxylic acid dimethyl ester | 159494-63-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7,8-Dichloro-1-methyl-4,5-dihydro-1H-benzo[g]indole-2,3-dicarboxylic acid dimethyl ester
• CAS: 159494-63-0
• 化学式: C₁₇H₁₅Cl₂NO₄
• 分子量: 368.216
• InChiKey: KDWWAFZVEHGTQP-UHFFFAOYSA-N

物化性质

• 沸点：
  504.3±50.0 °C(predicted)
• 密度：
  1.44±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  7,8-Dichloro-1-methyl-4,5-dihydro-1H-benzo[g]indole-2,3-dicarboxylic acid dimethyl ester 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以84%的产率得到7,8-Dichloro-1-methyl-1H-benzo[g]indole-2,3-dicarboxylic acid dimethyl ester
  参考文献：
  名称：

  Synthesis and in vitro anticancer activity evaluation of biscarbamic esters of 2,3-bis (hydroxymethyl)-1-methyl-7- and 7,8 -substituted-benzo[g]indoles

  摘要：

  A series of various bis(hydroxymethyl) carbamate derivatives of 7-mono- and 7,8-disubstituted-1-methyl-benzo[g]indoles was prepared in order to evaluate their cytostatic and cytotoxic activities in vitro. Compounds 2a-h showed significant tumor growth inhibition activity and were more potent than the 4,5-dihydrobenzo[g]indole analogues previously described. Compound 2a was the most active in this series, showing high activity and selectivity for some human cancer cell lines in the National Cancer Institute screen. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(97)00016-5
• 作为产物：
  描述：

  2,3-dimethoxycarbonyl-7,8-dichloro-4,5-dihydro-1H-benzoindole 、 碘甲烷 在 氢氧化钾 作用下， 生成 7,8-Dichloro-1-methyl-4,5-dihydro-1H-benzo[g]indole-2,3-dicarboxylic acid dimethyl ester
  参考文献：
  名称：

  Pinna; Pirisi; Paglietti, Revista Bras il eira de Farmaco gnosia, 1994, vol. 49, # 2, p. 121 - 126

  摘要：

  DOI：