(4-Formyl-6,7-dimethoxy-isoquinolin-1-ylmethyl)-carbamic acid tert-butyl ester | 293735-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (4-Formyl-6,7-dimethoxy-isoquinolin-1-ylmethyl)-carbamic acid tert-butyl ester
• CAS: 293735-28-1
• 化学式: C₁₈H₂₂N₂O₅
• 分子量: 346.383
• InChiKey: RCFRENAROMBLEC-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  (4-Formyl-6,7-dimethoxy-isoquinolin-1-ylmethyl)-carbamic acid tert-butyl ester 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 1-Aminomethyl-6,7-dimethoxy-isoquinoline-4-carbaldehyde
  参考文献：
  名称：

  1-Aminomethylisoquinoline-4-carboxylates as novel dipeptidylpeptidase IV inhibitors

  摘要：

  Structure-activity relationship within a series of 1-aminoalkylisoquinoline-4-carboxylates as inhibitors of DPP-IV is described. A primary aminomethyl group is required to maintain biological activity. Substitution of the isoquinoline at the 6- and 8-positions with methoxy groups increases potency to 53 times that of the lead compound SDZ 029-576. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00286-9
• 作为产物：
  描述：

  1-(tert-butoxycarbonylaminomethyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid ethyl ester 在 manganese(IV) oxide 、 sodium aluminum diethyl dihydride 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 (4-Formyl-6,7-dimethoxy-isoquinolin-1-ylmethyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  1-Aminomethylisoquinoline-4-carboxylates as novel dipeptidylpeptidase IV inhibitors

  摘要：

  Structure-activity relationship within a series of 1-aminoalkylisoquinoline-4-carboxylates as inhibitors of DPP-IV is described. A primary aminomethyl group is required to maintain biological activity. Substitution of the isoquinoline at the 6- and 8-positions with methoxy groups increases potency to 53 times that of the lead compound SDZ 029-576. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00286-9